Faiz Gani1,2, Utkarsh Goel1, Joseph K Canner1,2, Christian F Meyer3, Fabian M Johnston1. 1. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. 2. Department of Surgery, Johns Hopkins Surgery Center for Outcomes Research, Johns Hopkins University School of Medicine, Baltimore, Maryland. 3. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Abstract
BACKGROUND: Because of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought to describe patterns of care and clinical outcomes for patients with DSCRT. METHODS: Data from the National Cancer Database were used to identify 491 patients aged 18 years or older diagnosed with DSRCT between 2004 and 2014. Multivariable Cox proportional hazards regression analysis was used to identify factors associated with overall survival (OS). RESULTS: Among all patients, 41.2% (n = 200), underwent surgical resection of their primary tumor, chemotherapy was administered to 86.5% (n = 415) of patients, while radiation therapy was administered to 13.0% (n = 63) of patients. Over the study, 69.7% of patients died with a median OS of 25.9 months (interquartile range [IQR]: 22.7-27.5); 1-, 3-, and 5-year OS were 78.6%, 32.3%, and 18.4%, respectively. On multivariable analysis, stage IV disease (Hazard Ratio [HR] = 2.12, 95% CI: 1.41-3.18), receipt of surgery (HR = 0.68, 95% CI: 0.50-0.91), chemotherapy (HR = 0.52, 95% CI: 0.35-0.78), or radiation therapy (HR = 0.55, 95% CI: 0.33-0.92) were independently associated with OS. CONCLUSIONS: Although receipt of multimodality treatment may lead to improved survival, further research and clinical trials are required to establish best practices for the care of DSRCT.
BACKGROUND: Because of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought to describe patterns of care and clinical outcomes for patients with DSCRT. METHODS: Data from the National Cancer Database were used to identify 491 patients aged 18 years or older diagnosed with DSRCT between 2004 and 2014. Multivariable Cox proportional hazards regression analysis was used to identify factors associated with overall survival (OS). RESULTS: Among all patients, 41.2% (n = 200), underwent surgical resection of their primary tumor, chemotherapy was administered to 86.5% (n = 415) of patients, while radiation therapy was administered to 13.0% (n = 63) of patients. Over the study, 69.7% of patients died with a median OS of 25.9 months (interquartile range [IQR]: 22.7-27.5); 1-, 3-, and 5-year OS were 78.6%, 32.3%, and 18.4%, respectively. On multivariable analysis, stage IV disease (Hazard Ratio [HR] = 2.12, 95% CI: 1.41-3.18), receipt of surgery (HR = 0.68, 95% CI: 0.50-0.91), chemotherapy (HR = 0.52, 95% CI: 0.35-0.78), or radiation therapy (HR = 0.55, 95% CI: 0.33-0.92) were independently associated with OS. CONCLUSIONS: Although receipt of multimodality treatment may lead to improved survival, further research and clinical trials are required to establish best practices for the care of DSRCT.
Authors: Celso Abdon Mello; Fernando Augusto Batista Campos; Tiago Goss Santos; Maria Leticia Gobo Silva; Giovana Tardin Torrezan; Felipe D'Almeida Costa; Maria Nirvana Formiga; Ulisses Nicolau; Antonio Geraldo Nascimento; Cassia Silva; Maria Paula Curado; Suely Akiko Nakagawa; Ademar Lopes; Samuel Aguiar Journal: Cancers (Basel) Date: 2021-01-28 Impact factor: 6.639
Authors: Fernando Campos; Daniel L Coutinho; Maria Letícia G Silva; Ademar Lopes; Antônio Nascimento; Samuel Aguiar Júnior; Ulisses R Nicolau; Maria Nirvana Formiga; Felipe D'Almeida Costa; Celso Mello Journal: Sarcoma Date: 2020-10-28
Authors: Christoph E Heilig; Manuela Badoglio; Myriam Labopin; Stefan Fröhling; Simona Secondino; Jürgen Heinz; Emmanuelle Nicolas-Virelizier; Didier Blaise; Clément Korenbaum; Armando Santoro; Mareike Verbeek; William Krüger; Salvatore Siena; Jakob R Passweg; Massimo Di Nicola; Jose Rifón; Peter Dreger; Ulrike Koehl; Christian Chabannon; Paolo Pedrazzoli Journal: ESMO Open Date: 2020-10