Literature DB >> 30843487

Role of Autophagy in Chronic Liver Inflammation and Fibrosis.

Yu-Jen Tseng1, Ling Dong1,2, Yu-Feng Liu3, Nuo Xu4, Wei Ma1, Shu-Qiang Weng1,2, Harry L A Janssen5, Sheng-Di Wu1,2.   

Abstract

Autophagy entails the removal of dysfunctional components to maintain cellular homeostasis. Over the years, studies of autophagy demonstrated its complex physiological and pathological roles in the liver. Apart from regulation of normal metabolic functions such as glycogenolysis, glycogenesis, and β-oxidation, autophagy also contributes to the modulation of various liver diseases. In this review, we provide a concise overview of the role of autophagy in regulating hepatic metabolism in healthy conditions and various chronic liver diseases. A well-rounded understanding of the role of autophagy may provide insight for future medical advancements in the field of hepatology. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Autophagy; chronic liver inflammation; fibrosis; lipophagy; macroautophagy; microautophagy.

Mesh：

Year:  2019        PMID： 30843487     DOI： 10.2174/1389203720666190305165203

Source DB:  PubMed          Journal:  Curr Protein Pept Sci        ISSN： 1389-2037            Impact factor:   3.272


  6 in total

1.  Loss of JNK-Associated Leucine Zipper Protein Promotes Peritoneal Dialysis-Related Peritoneal Fibrosis.

Authors:  Maoqing Tian; Lu Zhang; Yujuan Wang; Meili Deng; Cancan Peng; Wei Liang; Guohua Ding; Bo Shen; Huiming Wang
Journal:  Kidney Dis (Basel)       Date:  2022-02-01

2.  FBW7 Regulates the Autophagy Signal in Mesangial Cells Induced by High Glucose.

Authors:  Chenlin Gao; Fang Fan; Jiao Chen; Yang Long; Shi Tang; Chunxia Jiang; Yong Xu
Journal:  Biomed Res Int       Date:  2019-04-21       Impact factor: 3.411

3.  Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.

Authors:  Yuqin Wang; Chunling Li; Jingya Gu; Chang Chen; Jiaxin Duanmu; Jing Miao; Wenjuan Yao; Jinhua Tao; Mengjue Tu; Biao Xiong; Lingling Zhao; Zhaoguo Liu
Journal:  J Cell Mol Med       Date:  2019-11-19       Impact factor: 5.310

4.  Transcription factor EB‑mediated autophagy promotes dermal fibroblast differentiation and collagen production by regulating endoplasmic reticulum stress and autophagy‑dependent secretion.

Authors:  Ling Zhou; Zeming Liu; Sichao Chen; Jing Qiu; Qianqian Li; Shipei Wang; Wei Zhou; Danyang Chen; Guang Yang; Liang Guo
Journal:  Int J Mol Med       Date:  2020-12-09       Impact factor: 4.101

5.  In vivo Therapeutic Effects and Mechanisms of Hydroxyasiaticoside Combined With Praziquantel in the Treatment of Schistosomiasis Induced Hepatic Fibrosis.

Authors:  Huilong Fang; Ling Yu; Da You; Nan Peng; Wanbei Guo; Junjie Wang; Xing Zhang
Journal:  Front Bioeng Biotechnol       Date:  2021-01-22

6.  Taurine Attenuates Oxidized Fish Oil-Induced Oxidative Stress and Lipid Metabolism Disorder in Mice.

Authors:  Qiuping Guo; Lingyu Zhang; Yunju Yin; Saiming Gong; Yuhuan Yang; Sisi Chen; Mengmeng Han; Yehui Duan
Journal:  Antioxidants (Basel)       Date:  2022-07-18
  6 in total

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