Literature DB >> 3084295

Pyruvate utilization by synaptosomes is independent of calcium.

R A Kauppinen, D G Nicholls.   

Abstract

The significance of Ca2+ is assessed for the activation of pyruvate by intact nerve terminals (synaptosomes). Titration of glucose-depleted synaptosomes with pyruvate in the presence of either veratridine or uncoupler stimulates respiration in a Ca2+-independent manner. Additionally, the ability of exogenous pyruvate to support the mitochondrial membrane potential in situ is independent of Ca2+. It is concluded that Ca2+ does not regulate pyruvate oxidation in intact synaptosomes.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3084295     DOI： 10.1016/0014-5793(86)80484-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Dehydrogenase activation by Ca2+ in cells and tissues.

Authors:  R G Hansford
Journal:  J Bioenerg Biomembr       Date:  1991-12       Impact factor: 2.945

Review 2.  Control of respiration and ATP synthesis in mammalian mitochondria and cells.

Authors:  G C Brown
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

3.  Dual effect of pyruvate in isolated nerve terminals: generation of reactive oxygen species and protection of aconitase.

Authors:  Laszlo Tretter; Balint Liktor; Vera Adam-Vizi
Journal:  Neurochem Res       Date:  2005-10       Impact factor: 3.996

4.  Stimulation of respiration by mitogens in rat thymocytes is independent of mitochondrial calcium.

Authors:  P L Lakin-Thomas; M D Brand
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

5.  Motor terminal degeneration unaffected by activity changes in SOD1(G93A) mice; a possible role for glycolysis.

Authors:  Dario I Carrasco; Edyta K Bichler; Mark M Rich; Xueyong Wang; Kevin L Seburn; Martin J Pinter
Journal:  Neurobiol Dis       Date:  2012-06-29       Impact factor: 5.996

6.  Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure.

Authors:  Sung W Choi; Akos A Gerencser; David G Nicholls
Journal:  J Neurochem       Date:  2009-03-23       Impact factor: 5.372

7.  The role of cytosolic free calcium in the regulation of pyruvate dehydrogenase in synaptosomes.

Authors:  H M Huang; L Toral-Barza; K F Sheu; G E Gibson
Journal:  Neurochem Res       Date:  1994-01       Impact factor: 3.996

8.  Relationships between the neuronal sodium/potassium pump and energy metabolism. Effects of K+, Na+, and adenosine triphosphate in isolated brain synaptosomes.

Authors:  M Erecińska; F Dagani
Journal:  J Gen Physiol       Date:  1990-04       Impact factor: 4.086

9.  Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply.

Authors:  Marten Szibor; Zemfira Gizatullina; Timur Gainutdinov; Thomas Endres; Grazyna Debska-Vielhaber; Matthias Kunz; Niki Karavasili; Kerstin Hallmann; Frank Schreiber; Alexandra Bamberger; Michael Schwarzer; Torsten Doenst; Hans-Jochen Heinze; Volkmar Lessmann; Stefan Vielhaber; Wolfram S Kunz; Frank N Gellerich
Journal:  J Biol Chem       Date:  2020-02-24       Impact factor: 5.157
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.