Literature DB >> 30840872

Advancing Chemokine GPCR Structure Based Drug Discovery.

Suwen Zhao1, Beili Wu2, Raymond C Stevens3.   

Abstract

In this issue of Structure, Apel et al., (2019) provide structural insight into the inhibition of a human chemokine G-protein-coupled receptor by a small-molecule antagonist, which advances our understanding of drug design principles for this complex family of receptors.
Copyright © 2019. Published by Elsevier Ltd.

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Year:  2019        PMID: 30840872     DOI: 10.1016/j.str.2019.02.004

Source DB:  PubMed          Journal:  Structure        ISSN: 0969-2126            Impact factor:   5.006


  8 in total

Review 1.  AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors.

Authors:  Xin-Heng He; Chong-Zhao You; Hua-Liang Jiang; Yi Jiang; H Eric Xu; Xi Cheng
Journal:  Acta Pharmacol Sin       Date:  2022-07-01       Impact factor: 6.150

Review 2.  Role of chemokine systems in cancer and inflammatory diseases.

Authors:  Hongyi Li; Min Wu; Xia Zhao
Journal:  MedComm (2020)       Date:  2022-06-08

3.  Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.

Authors:  Ram Prasad Bhusal; Pramod Aryal; Shankar Raj Devkota; Rina Pokhrel; Menachem J Gunzburg; Simon R Foster; Herman D Lim; Richard J Payne; Matthew C J Wilce; Martin J Stone
Journal:  Proc Natl Acad Sci U S A       Date:  2022-03-01       Impact factor: 12.779

4.  A Scintillation Proximity Assay for Real-Time Kinetic Analysis of Chemokine-Chemokine Receptor Interactions.

Authors:  Stefanie Alexandra Eberle; Martin Gustavsson
Journal:  Cells       Date:  2022-04-13       Impact factor: 7.666

Review 5.  Latest update on chemokine receptors as therapeutic targets.

Authors:  Wing Yee Lai; Anja Mueller
Journal:  Biochem Soc Trans       Date:  2021-06-30       Impact factor: 5.407

6.  Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5.

Authors:  Hui Zhang; Kun Chen; Qiuxiang Tan; Qiang Shao; Shuo Han; Chenhui Zhang; Cuiying Yi; Xiaojing Chu; Ya Zhu; Yechun Xu; Qiang Zhao; Beili Wu
Journal:  Nat Commun       Date:  2021-07-06       Impact factor: 14.919

7.  Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design.

Authors:  Shaoyong Lu; Xinheng He; Zhao Yang; Zongtao Chai; Shuhua Zhou; Junyan Wang; Ashfaq Ur Rehman; Duan Ni; Jun Pu; Jinpeng Sun; Jian Zhang
Journal:  Nat Commun       Date:  2021-08-05       Impact factor: 14.919

8.  Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs.

Authors:  Regan Raines; Ian McKnight; Hunter White; Kaitlyn Legg; Chan Lee; Wei Li; Peter H U Lee; Joon W Shim
Journal:  Biomedicines       Date:  2022-03-03
  8 in total

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