Serena Bianchi1, Stefan Fuertinger2, Hailey Huddleston1, Steven J Frucht3, Kristina Simonyan4,5,6. 1. Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA. 2. Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt am Main, Germany. 3. Department of Neurology, New York University, New York, New York, USA. 4. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. 5. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. 6. Harvard Medical School, Boston, Massachusetts, USA.
Abstract
BACKGROUND: Task-specific focal dystonias selectively affect movements during the production of highly learned and complex motor behaviors. Manifestation of some task-specific focal dystonias, such as musician's dystonia, has been associated with excessive practice and overuse, whereas the etiology of others remains largely unknown. OBJECTIVES: In this study, we aimed to examine the neural correlates of task-specific dystonias in order to determine their disorder-specific pathophysiological traits. METHODS: Using multimodal neuroimaging analyses of resting-state functional connectivity, voxel-based morphometry and tract-based spatial statistics, we examined functional and structural abnormalities that are both common to and distinct between four different forms of task-specific focal dystonias. RESULTS: Compared to the normal state, all task-specific focal dystonias were characterized by abnormal recruitment of parietal and premotor cortices that are necessary for both modality-specific and heteromodal control of the sensorimotor network. Contrasting the laryngeal and hand forms of focal dystonia revealed distinct patterns of sensorimotor integration and planning, again involving parietal cortex in addition to inferior frontal gyrus and anterior insula. On the other hand, musician's dystonia compared to nonmusician's dystonia was shaped by alterations in primary and secondary sensorimotor cortices together with middle frontal gyrus, pointing to impairments of sensorimotor guidance and executive control. CONCLUSION: Collectively, this study outlines a specialized footprint of functional and structural alterations in different forms of task-specific focal dystonia, all of which also share a common pathophysiological framework involving premotor-parietal aberrations.
BACKGROUND: Task-specific focal dystonias selectively affect movements during the production of highly learned and complex motor behaviors. Manifestation of some task-specific focal dystonias, such as musician's dystonia, has been associated with excessive practice and overuse, whereas the etiology of others remains largely unknown. OBJECTIVES: In this study, we aimed to examine the neural correlates of task-specific dystonias in order to determine their disorder-specific pathophysiological traits. METHODS: Using multimodal neuroimaging analyses of resting-state functional connectivity, voxel-based morphometry and tract-based spatial statistics, we examined functional and structural abnormalities that are both common to and distinct between four different forms of task-specific focal dystonias. RESULTS: Compared to the normal state, all task-specific focal dystonias were characterized by abnormal recruitment of parietal and premotor cortices that are necessary for both modality-specific and heteromodal control of the sensorimotor network. Contrasting the laryngeal and hand forms of focal dystonia revealed distinct patterns of sensorimotor integration and planning, again involving parietal cortex in addition to inferior frontal gyrus and anterior insula. On the other hand, musician's dystonia compared to nonmusician's dystonia was shaped by alterations in primary and secondary sensorimotor cortices together with middle frontal gyrus, pointing to impairments of sensorimotor guidance and executive control. CONCLUSION: Collectively, this study outlines a specialized footprint of functional and structural alterations in different forms of task-specific focal dystonia, all of which also share a common pathophysiological framework involving premotor-parietal aberrations.
Authors: Cathérine C S Delnooz; Rick C Helmich; W P Medendorp; Bart P C Van de Warrenburg; Ivan Toni Journal: Hum Brain Mapp Date: 2011-11-24 Impact factor: 5.038
Authors: Adeen Flinker; Anna Korzeniewska; Avgusta Y Shestyuk; Piotr J Franaszczuk; Nina F Dronkers; Robert T Knight; Nathan E Crone Journal: Proc Natl Acad Sci U S A Date: 2015-02-17 Impact factor: 11.205
Authors: Shabbir Hussain I Merchant; Eleni Frangos; Jacob Parker; Megan Bradson; Tianxia Wu; Felipe Vial-Undurraga; Giorgio Leodori; M C Bushnell; Silvina G Horovitz; Mark Hallett; Traian Popa Journal: Brain Date: 2020-06-01 Impact factor: 13.501
Authors: Kristina Simonyan; Stefan K Ehrlich; Richard Andersen; Jonathan Brumberg; Frank Guenther; Mark Hallett; Matthew A Howard; José Del R Millán; Richard B Reilly; Tanja Schultz; Davide Valeriani Journal: Mov Disord Date: 2022-08-10 Impact factor: 9.698
Authors: Kristina Simonyan; Julie Barkmeier-Kraemer; Andrew Blitzer; Mark Hallett; John F Houde; Teresa Jacobson Kimberley; Laurie J Ozelius; Michael J Pitman; Robert Mark Richardson; Nutan Sharma; Kristine Tanner Journal: Neurology Date: 2021-04-15 Impact factor: 11.800
Authors: Marenka Smit; Alberto Albanese; Monika Benson; Mark J Edwards; Holm Graessner; Michael Hutchinson; Robert Jech; Joachim K Krauss; Francesca Morgante; Belen Pérez Dueñas; Richard B Reilly; Michele Tinazzi; Maria Fiorella Contarino; Marina A J Tijssen Journal: Front Neurol Date: 2021-06-03 Impact factor: 4.003