Literature DB >> 3084035

The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting.

P Brundin, O Isacson, F H Gage, A Prochiantz, A Björklund.   

Abstract

Mice were first administered intrastriatal injections of 6-hydroxydopamine and subsequently a sub-group was given neural cell suspension grafts prepared from 14-day-old fetal ventral mesencephalic mouse tissue. Six and 8 weeks after transplantation the mice in the grafted group exhibited a significant reduction in amphetamine-induced turning behaviour towards the lesioned side compared to non-grafted lesioned controls. Six of the 7 mice that had surviving grafts containing histofluorescent dopamine neurons eventually showed a reversed motor side bias with more amphetamine-induced turning in a direction away from the transplant.

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Year:  1986        PMID： 3084035     DOI： 10.1016/0006-8993(86)91316-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.

Authors:  Haruhisa Inoue; Ling Lin; Xinhua Lee; Zhaohui Shao; Shannon Mendes; Pamela Snodgrass-Belt; Harry Sweigard; Tom Engber; Blake Pepinsky; Lichuan Yang; M Flint Beal; Sha Mi; Ole Isacson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-28       Impact factor: 11.205

2.  Xenografting of fetal pig ventral mesencephalon corrects motor asymmetry in the rat model of Parkinson's disease.

Authors:  T K Huffaker; B D Boss; A S Morgan; N T Neff; R E Strecker; M S Spence; R Miao
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

3.  Studies on the striatal dopamine uptake system of weaver mutant mice and effects of ventral mesencephalic grafts.

Authors:  L C Triarhou; E H Stotz; W C Low; J Norton; B Ghetti; B Landwehrmeyer; J M Palacios; J R Simon
Journal:  Neurochem Res       Date:  1994-11       Impact factor: 3.996

4.  Behavioural effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease.

Authors:  P Brundin; O G Nilsson; R E Strecker; O Lindvall; B Astedt; A Björklund
Journal:  Exp Brain Res       Date:  1986       Impact factor: 1.972

5.  Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: ultrastructural evidence for synapse formation using tyrosine hydroxylase immunocytochemistry.

Authors:  D J Clarke; P Brundin; R E Strecker; O G Nilsson; A Björklund; O Lindvall
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

6.  Intrastriatal implants of mesencephalic cell suspensions in weaver mutant mice: ultrastructural relationships of dopaminergic dendrites and axons issued from the graft.

Authors:  L C Triarhou; P Brundin; G Doucet; J Norton; A Björklund; B Ghetti
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

7.  Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease.

Authors:  X G Xia; T Harding; M Weller; A Bieneman; J B Uney; J B Schulz
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

8.  Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization.

Authors:  Eva Auffenberg; Angela Jurik; Corinna Mattusch; Rainer Stoffel; Andreas Genewsky; Christian Namendorf; Roland M Schmid; Gerhard Rammes; Martin Biel; Manfred Uhr; Sven Moosmang; Stylianos Michalakis; Carsten T Wotjak; Christoph K Thoeringer
Journal:  Sci Rep       Date:  2016-01-13       Impact factor: 4.379

9.  Brain Lateralization in Mice Is Associated with Zinc Signaling and Altered in Prenatal Zinc Deficient Mice That Display Features of Autism Spectrum Disorder.

Authors:  Stefanie Grabrucker; Jasmin C Haderspeck; Ann Katrin Sauer; Nadine Kittelberger; Harun Asoglu; Alireza Abaei; Volker Rasche; Michael Schön; Tobias M Boeckers; Andreas M Grabrucker
Journal:  Front Mol Neurosci       Date:  2018-01-15       Impact factor: 5.639

10.  Unilateral Botulinum Neurotoxin-A Injection into the Striatum of C57BL/6 Mice Leads to a Different Motor Behavior Compared with Rats.

Authors:  Veronica Antipova; Andreas Wree; Carsten Holzmann; Teresa Mann; Nicola Palomero-Gallagher; Karl Zilles; Oliver Schmitt; Alexander Hawlitschka
Journal:  Toxins (Basel)       Date:  2018-07-17       Impact factor: 4.546
  10 in total

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