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Literature DB >> 30838875

Paracellular calcium transport in the proximal tubule and the formation of kidney stones.

Abstract

The proximal tubule (PT) is responsible for the majority of calcium reabsorption by the kidney. Most PT calcium transport appears to be passive, although the molecular facilitators have not been well established. Emerging evidence supports a major role for PT calcium transport in idiopathic hypercalciuria and the development of kidney stones. This review will cover recent developments in our understanding of PT calcium transport and the role of the PT in kidney stone formation.

Entities: Chemical

Keywords: calcium; hypercalciuria; kidney stones; nephrocalcinosis; proximal tubule

Mesh：

Substances：

Year: 2019 PMID： 30838875 PMCID： PMC6580246 DOI： 10.1152/ajprenal.00519.2018

Source DB: PubMed Journal: Am J Physiol Renal Physiol ISSN： 1522-1466

43 in total

1. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels.

Authors: T Ma; B Yang; A Gillespie; E J Carlson; C J Epstein; A S Verkman
Journal: J Biol Chem Date: 1998-02-20 Impact factor: 5.157

Review 2. Claudins and the kidney.

Authors: Jianghui Hou; Madhumitha Rajagopal; Alan S L Yu
Journal: Annu Rev Physiol Date: 2012-11-05 Impact factor: 19.318

3. Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules.

Authors: Shigeaki Muto; Masaki Hata; Junichi Taniguchi; Shuichi Tsuruoka; Kazumasa Moriwaki; Mitinori Saitou; Kyoko Furuse; Hiroyuki Sasaki; Akio Fujimura; Masashi Imai; Eiji Kusano; Shoichiro Tsukita; Mikio Furuse
Journal: Proc Natl Acad Sci U S A Date: 2010-04-12 Impact factor: 11.205

1. Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.

Authors: Qianlin Song; Wenbiao Liao; Xin Chen; Ziqi He; Bin Li; Junwei Liu; Lang Liu; Yunhe Xiong; Chao Song; Sixing Yang
Journal: Oxid Med Cell Longev Date: 2021-10-06 Impact factor: 6.543

2. Claudins in kidney health and disease.

Authors: Chor Ho Jo; Sua Kim; Gheun-Ho Kim
Journal: Kidney Res Clin Pract Date: 2022-03-15

2 in total

Paracellular calcium transport in the proximal tubule and the formation of kidney stones.

1. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels.

Review 2. Claudins and the kidney.

3. Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules.

4. Claudin-2 is selectively expressed in proximal nephron in mouse kidney.

5. Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes.

6. Claudin-1 contributes to the epithelial barrier function in MDCK cells.

7. Reflection coefficients and water permeability in rat proximal tubule.

8. Differential expression of claudin tight junction proteins in the human cortical nephron.

9. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function.

10. Osmotic gradient dependence of osmotic water permeability in rabbit proximal convoluted tubule.

1. Oxalate Activates Autophagy to Induce Ferroptosis of Renal Tubular Epithelial Cells and Participates in the Formation of Kidney Stones.

2. Claudins in kidney health and disease.