Yuechao Zhao1, Shaohui He1, Haitao Sun1, Xiaopan Cai1, Xin Gao1, Peng Wang2, Haifeng Wei3, Wei Xu4, Jianru Xiao5. 1. Department of Orthopedic Oncology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China. 2. Department of Radiology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China. 3. Department of Orthopedic Oncology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China. weihfspine@163.com. 4. Department of Orthopedic Oncology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China. xuweichangzheng@hotmail.com. 5. Department of Orthopedic Oncology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China. jianruxiao83@163.com.
Abstract
PURPOSE: The aim of the study was to report the long-term outcomes and analyze the potential prognostic factors that may contribute to symptomatic patients with aneurysmal bone cyst (ABC) of the spine undergoing surgical treatments. METHODS: A retrospective analysis of consecutive patients with ABCs of the spine was performed. The clinical features were reviewed, and the disease-free survival (DFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method. Factors with p values ≤ 0.05 were subjected to multivariate analysis by Cox proportional hazards model to identify the independent prognostic contributors. p values < 0.05 were considered statistically significant. RESULTS: A total of 42 patients with ABCs of the spine were included in the study. All patients received surgical treatments. The mean follow-up period was 41.3 months (median 39.5, range 24-64). Local recurrence was detected in eight patients after surgery in our center, whereas death occurred in three patients. The estimated 5-year DFS and OS rate was 54.1% and 76.8%, respectively. The statistical analyses indicated that both en bloc resection and primary/secondary tumor status were independent prognostic factors for DFS. CONCLUSIONS: Secondary ABC status may be associated with worse prognosis, and en bloc resection remains the treatment of choice for ABCs with neurologic deficits or spinal instability of the spine, which is correlated with better prognosis for local tumor control. These slides can be retrieved under Electronic Supplementary Material.
PURPOSE: The aim of the study was to report the long-term outcomes and analyze the potential prognostic factors that may contribute to symptomatic patients with aneurysmal bone cyst (ABC) of the spine undergoing surgical treatments. METHODS: A retrospective analysis of consecutive patients with ABCs of the spine was performed. The clinical features were reviewed, and the disease-free survival (DFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method. Factors with p values ≤ 0.05 were subjected to multivariate analysis by Cox proportional hazards model to identify the independent prognostic contributors. p values < 0.05 were considered statistically significant. RESULTS: A total of 42 patients with ABCs of the spine were included in the study. All patients received surgical treatments. The mean follow-up period was 41.3 months (median 39.5, range 24-64). Local recurrence was detected in eight patients after surgery in our center, whereas death occurred in three patients. The estimated 5-year DFS and OS rate was 54.1% and 76.8%, respectively. The statistical analyses indicated that both en bloc resection and primary/secondary tumor status were independent prognostic factors for DFS. CONCLUSIONS: Secondary ABC status may be associated with worse prognosis, and en bloc resection remains the treatment of choice for ABCs with neurologic deficits or spinal instability of the spine, which is correlated with better prognosis for local tumor control. These slides can be retrieved under Electronic Supplementary Material.
Entities:
Keywords:
Aneurysmal bone cyst; Disease-free survival; En bloc; Prognosis; Recurrence
Authors: Charles G Fisher; Christian P DiPaola; Timothy C Ryken; Mark H Bilsky; Christopher I Shaffrey; Sigurd H Berven; James S Harrop; Michael G Fehlings; Stefano Boriani; Dean Chou; Meic H Schmidt; David W Polly; Roberto Biagini; Shane Burch; Mark B Dekutoski; Aruna Ganju; Peter C Gerszten; Ziya L Gokaslan; Michael W Groff; Norbert J Liebsch; Ehud Mendel; Scott H Okuno; Shreyaskumar Patel; Laurence D Rhines; Peter S Rose; Daniel M Sciubba; Narayan Sundaresan; Katsuro Tomita; Peter P Varga; Luiz R Vialle; Frank D Vrionis; Yoshiya Yamada; Daryl R Fourney Journal: Spine (Phila Pa 1976) Date: 2010-10-15 Impact factor: 3.468
Authors: S Boriani; F De Iure; L Campanacci; A Gasbarrini; S Bandiera; R Biagini; F Bertoni; P Picci Journal: Spine (Phila Pa 1976) Date: 2001-01-01 Impact factor: 3.468
Authors: Mark H Bilsky; Yoshiya Yamada; Kamil M Yenice; Michael Lovelock; Margie Hunt; Philip H Gutin; Steven A Leibel Journal: Neurosurgery Date: 2004-04 Impact factor: 4.654
Authors: Giulia Del Sindaco; Pablo Berlanga; Laurence Brugières; Eric Thebault; Giovanna Mantovani; Philippe Wicart; Agnès Linglart Journal: Front Endocrinol (Lausanne) Date: 2021-07-16 Impact factor: 5.555