Literature DB >> 30837277

Tumor Landscapes: β-Catenin Drives Immune Desertification.

Denarda Dangaj1, David Barras1, George Coukos2.   

Abstract

Immune checkpoint blockade therapy requires a preestablished activated immune landscape. Understanding tumor-intrinsic mechanisms that lead to T-cell desertification is key to resensitizing them to such therapies. The WNT/β-catenin tumor-intrinsic signaling is emerging as an immune exclusion pathway that holds high promise to counteract resistance to immunotherapy.See related article by Luke et al., p. 3074. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 30837277     DOI： 10.1158/1078-0432.CCR-19-0188

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  4 in total

Review 1.  Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.

Authors:  Violena Pietrobon; Alessandra Cesano; Francesco Marincola; Jakob Nikolas Kather
Journal:  Front Immunol       Date:  2021-01-27       Impact factor: 7.561

2.  A Retrospective Analysis of a Cohort of Patients Treated With Immune Checkpoint Blockade in Recurrent/Metastatic Head and Neck Cancer.

Authors:  Michel Bila; Jeroen Van Dessel; Maximiliaan Smeets; Vincent Vander Poorten; Sandra Nuyts; Jeroen Meulemans; Paul M Clement
Journal:  Front Oncol       Date:  2022-01-27       Impact factor: 6.244

3.  Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery.

Authors:  Jiaojiao Zhu; Ruimin Chang; Benliang Wei; Yao Fu; Xiang Chen; Hong Liu; Wenhu Zhou
Journal:  Research (Wash D C)       Date:  2022-09-02

4.  Reprogramming of tumor-associated macrophages by targeting β-catenin/FOSL2/ARID5A signaling: A potential treatment of lung cancer.

Authors:  Poonam Sarode; Xiang Zheng; Georgia A Giotopoulou; Andreas Weigert; Carste Kuenne; Stefan Günther; Aleksandra Friedrich; Stefan Gattenlöhner; Thorsten Stiewe; Bernhard Brüne; Friedrich Grimminger; Georgios T Stathopoulos; Soni Savai Pullamsetti; Werner Seeger; Rajkumar Savai
Journal:  Sci Adv       Date:  2020-06-05       Impact factor: 14.136
  4 in total

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