Literature DB >> 30836793

Pharmacological inhibition of Bax-induced cell death: Bax-inhibiting peptides and small compounds inhibiting Bax.

Kelsey Jensen1, David Jasen WuWong1, Sean Wong1, Mieko Matsuyama1, Shigemi Matsuyama1.   

Abstract

IMPACT STATEMENT: Bax induces mitochondria-dependent programed cell death. While cytotoxic drugs activating Bax have been developed for cancer treatment, clinically effective therapeutics suppressing Bax-induced cell death rescuing essential cells have not been developed. This mini-review will summarize previously reported Bax inhibitors including peptides, small compounds, and antibodies. We will discuss potential applications and the future direction of these Bax inhibitors.

Entities:  

Keywords:  Apoptosis; Bax; Bax inhibitor; Ku70; cell death; cell-penetrating peptide; drug delivery

Mesh：

Substances：

Year:  2019        PMID： 30836793      PMCID： PMC6552396          DOI： 10.1177/1535370219833624

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  72 in total

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Review 2.  Membrane permeability commonly shared among arginine-rich peptides.

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Review 3.  Transduction peptides: from technology to physiology.

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Journal:  Am J Hum Genet       Date:  2000-07-03       Impact factor: 11.025

6.  In vivo protein transduction: delivery of a biologically active protein into the mouse.

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Journal:  Science       Date:  1999-09-03       Impact factor: 47.728

7.  Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery.

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Journal:  J Biol Chem       Date:  2000-11-17       Impact factor: 5.157

8.  BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways.

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Journal:  Mol Med       Date:  2001-09       Impact factor: 6.354

9.  The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

Authors:  T Lindsten; A J Ross; A King; W X Zong; J C Rathmell; H A Shiels; E Ulrich; K G Waymire; P Mahar; K Frauwirth; Y Chen; M Wei; V M Eng; D M Adelman; M C Simon; A Ma; J A Golden; G Evan; S J Korsmeyer; G R MacGregor; C B Thompson
Journal:  Mol Cell       Date:  2000-12       Impact factor: 17.970

10.  Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.

Authors:  Jehangir S Wadia; Radu V Stan; Steven F Dowdy
Journal:  Nat Med       Date:  2004-02-08       Impact factor: 53.440
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  8 in total

1.  Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune-related Pathways in Mammalian Cells.

Authors:  Joshua D Bryant; Yuanjiu Lei; Jordyn J VanPortfliet; Ashley D Winters; A Phillip West
Journal:  Curr Protoc       Date:  2022-02

2.  A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer.

Authors:  Xu Zhang; Na Qin; Jingyi Fan; Chang Zhang; Qi Sun; Yayun Gu; Meng Zhu; Erbao Zhang; Juncheng Dai; Guangfu Jin; Hongxia Ma; Zhibin Hu; Hongbing Shen
Journal:  Cancer Biol Med       Date:  2022-09-02       Impact factor: 5.347

3.  Downregulation of LINC01857 Increases Sensitivity of Gastric Carcinoma Cells to Cisplatin.

Authors:  Yun Chen; Yanli Wu
Journal:  Comput Math Methods Med       Date:  2022-05-11       Impact factor: 2.809

Review 4.  Neuroprotective Effect of Physical Activity in Ischemic Stroke: Focus on the Neurovascular Unit.

Authors:  Hui Zhang; Qi Xie; Juan Hu
Journal:  Front Cell Neurosci       Date:  2022-03-04       Impact factor: 5.505

5.  Considerations on the Rational Design of Covalently Conjugated Cell-Penetrating Peptides (CPPs) for Intracellular Delivery of Proteins: A Guide to CPP Selection Using Glucarpidase as the Model Cargo Molecule.

Authors:  Yasaman Behzadipour; Shiva Hemmati
Journal:  Molecules       Date:  2019-11-26       Impact factor: 4.411

Review 6.  Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression.

Authors:  Ja Hyun Koo; Chang Yeob Han
Journal:  Biomolecules       Date:  2021-02-08

7.  Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury.

Authors:  Jin Xu; Dong Yu; Xiaolu Bai; Peng Zhang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

8.  Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.

Authors:  Lan Huang; Xizhou An; Yao Zhu; Kainan Zhang; Li Xiao; Xinyuan Yao; Xing Zeng; Shaoyan Liang; Jie Yu
Journal:  Cell Commun Signal       Date:  2022-08-16       Impact factor: 7.525
  8 in total

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