Melina da Silva Bernardes1, Carmen Lucia Antão Paiva2, Eduardo Ribeiro Paradela3, Marcos Papais Alvarenga4, Fernanda Ferreira Pereira3, Claudia Cristina Vasconcelos4, Regina Maria Papais Alvarenga4. 1. Graduate Progam in Neurology (PPGNEURO), Hospital Universitário Gaffrée e Guinle (HUGG), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Rio de Janeiro/RJ 20270-004, Brazil. Electronic address: melina.sbernardes@gmail.com. 2. Department of Genetics and Molecular Biology, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Frei Caneca 94, Rio de Janeiro/RJ 20211-040, Brazil. 3. Graduate Progam in Neurology (PPGNEURO), Hospital Universitário Gaffrée e Guinle (HUGG), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Rio de Janeiro/RJ 20270-004, Brazil. 4. Graduate Progam in Neurology (PPGNEURO), Hospital Universitário Gaffrée e Guinle (HUGG), Universidade Federal do Estado do Rio de Janeiro (UNIRIO), Rua Mariz e Barros 775, Rio de Janeiro/RJ 20270-004, Brazil; Department of Neurology, Hospital da Lagoa, Ministry of Health, Rua Jardim Botânico 501, Rio de Janeiro/RJ 22470-050, Brazil.
Abstract
BACKGROUND: The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population. METHODS: Association analyses between DR15 and the clinical and demographic variables were made. RESULTS: We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).
BACKGROUND: The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population. METHODS: Association analyses between DR15 and the clinical and demographic variables were made. RESULTS: We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).