Literature DB >> 30835961

What Is the "Relevant" Amyloid β42 Concentration?

Jevgenij A Raskatov1.   

Abstract

Alzheimer's amyloid beta can perform a wide variety of actions that are highly concentration dependent. This viewpoint aims to provide a framework for basic considerations on what might be considered brain-relevant concentrations of the peptide. Some implications for the therapeutic implementation of the recently emerged oligomer-to-fibril strategy are discussed.
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  amyloid beta-peptides; fibrils; oligomer-to-fibril conversion; oligomers; synaptic modulation

Mesh：

Substances：

Year:  2019        PMID： 30835961      PMCID： PMC6711386          DOI： 10.1002/cbic.201900097

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  31 in total

1.  Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

Authors:  Dominic M Walsh; Igor Klyubin; Julia V Fadeeva; William K Cullen; Roger Anwyl; Michael S Wolfe; Michael J Rowan; Dennis J Selkoe
Journal:  Nature       Date:  2002-04-04       Impact factor: 49.962

2.  Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection.

Authors:  Lujian Liao; Dongmei Cheng; Jian Wang; Duc M Duong; Tatyana G Losik; Marla Gearing; Howard D Rees; James J Lah; Allan I Levey; Junmin Peng
Journal:  J Biol Chem       Date:  2004-06-25       Impact factor: 5.157

Review 3.  Protein misfolding, functional amyloid, and human disease.

Authors:  Fabrizio Chiti; Christopher M Dobson
Journal:  Annu Rev Biochem       Date:  2006       Impact factor: 23.643

Review 4.  Alzheimer's disease.

Authors:  Henry W Querfurth; Frank M LaFerla
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 91.245

Review 5.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Authors:  Christian Haass; Dennis J Selkoe
Journal:  Nat Rev Mol Cell Biol       Date:  2007-02       Impact factor: 94.444

6.  Raft lipids as common components of human extracellular amyloid fibrils.

Authors:  Gerald P Gellermann; Thomas R Appel; Astrid Tannert; Anja Radestock; Peter Hortschansky; Volker Schroeckh; Christian Leisner; Tim Lütkepohl; Shmuel Shtrasburg; Christoph Röcken; Mordechai Pras; Reinhold P Linke; Stephan Diekmann; Marcus Fändrich
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-25       Impact factor: 11.205

7.  Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

Authors:  Efrat Abramov; Iftach Dolev; Hilla Fogel; Giuseppe D Ciccotosto; Eyal Ruff; Inna Slutsky
Journal:  Nat Neurosci       Date:  2009-12       Impact factor: 24.884

Review 8.  Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.

Authors:  Dennis J Selkoe
Journal:  Behav Brain Res       Date:  2008-02-17       Impact factor: 3.332

9.  Structure-neurotoxicity relationships of amyloid beta-protein oligomers.

Authors:  Kenjiro Ono; Margaret M Condron; David B Teplow
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-12       Impact factor: 11.205

10.  Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.

Authors:  Daniela Puzzo; Lucia Privitera; Elena Leznik; Mauro Fà; Agnieszka Staniszewski; Agostino Palmeri; Ottavio Arancio
Journal:  J Neurosci       Date:  2008-12-31       Impact factor: 6.167
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  5 in total

Review 1.  Is the p3 Peptide (Aβ17-40, Aβ17-42) Relevant to the Pathology of Alzheimer's Disease?1.

Authors:  Ariel J Kuhn; Jevgenij Raskatov
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

2.  From reaction kinetics to dementia: A simple dimer model of Alzheimer's disease etiology.

Authors:  Michael R Lindstrom; Manuel B Chavez; Elijah A Gross-Sable; Eric Y Hayden; David B Teplow
Journal:  PLoS Comput Biol       Date:  2021-07-19       Impact factor: 4.475

3.  Amyloid beta acts synergistically as a pro-inflammatory cytokine.

Authors:  Thomas J LaRocca; Alyssa N Cavalier; Christine M Roberts; Maddie R Lemieux; Pooja Ramesh; Micklaus A Garcia; Christopher D Link
Journal:  Neurobiol Dis       Date:  2021-08-28       Impact factor: 5.996

4.  Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Aβ42 Oligomers and Protect Synapses.

Authors:  Songlin Li; Eric Y Hayden; Veronica J Garcia; Dieu-Trang Fuchs; Julia Sheyn; David A Daley; Altan Rentsendorj; Tania Torbati; Keith L Black; Ueli Rutishauser; David B Teplow; Yosef Koronyo; Maya Koronyo-Hamaoui
Journal:  Front Immunol       Date:  2020-01-31       Impact factor: 8.786

5.  Amyloid-β oligomerization monitored by single-molecule stepwise photobleaching.

Authors:  Lara Dresser; Patrick Hunter; Fatima Yendybayeva; Alex L Hargreaves; Jamieson A L Howard; Gareth J O Evans; Mark C Leake; Steven D Quinn
Journal:  Methods       Date:  2020-06-13       Impact factor: 3.608
  5 in total

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