Tufan Çınar1, Metin Çağdaş2, İbrahim Rencüzoğulları2, Süleyman Karakoyun2, Yavuz Karabağ2, Mahmut Yesin3, Öznur Sadioğlu Çağdaş4, Halil İbrahim Tanboğa5. 1. a Department of Cardiology , Health Sciences University, Sultan Abdülhamid Han Training and Research Hospital , Istanbul , Turkey. 2. b Department of Cardiology , Kafkas University Medical Faculty , Kars , Turkey. 3. c Department of Cardiology , Kars Harakani State Hospital , Kars , Turkey. 4. d Department of Internal Medicine , Kafkas University Medical Faculty , Kars , Turkey. 5. e Department of Cardiology , Ataturk University Medical School , Erzurum , Turkey.
Abstract
OBJECTIVE: Although the prognostic efficacy of C-reactive protein (mg/L) and albumin levels (g/L) has been previously associated with poor prognosis in ST elevation myocardial infarction (STEMI), to the best of our knowledge, the prognostic efficacy of C-reactive protein/Albumin ratio (CAR) (mg/g) has not been investigated yet. Thus, this study aimed to investigate the potential efficacy of the CAR in predicting prognosis in STEMI patients. METHOD: We conducted a detailed investigation of 2437 patients with first STEMI treated with a primary percutaneous coronary intervention. After evaluation regarding to exclusion criteria, 2243 patients were found to be eligible for analysis. The mean follow-up of the study was 34 ± 15 months. RESULTS: The median CAR value of the study population was 2.70 (range: 1.44-4.76), and the patients were divided into three tertiles according to their CAR values. Kaplan-Meier survival analysis showed significantly lower in-hospital and long-term survival rates for the patients in a high CAR tertile. In addition, the CAR was found to be an independent predictor of all-cause mortality (Hazards ratio: 1.033, 95% Confidence Interval: 1.007-1.061, p = .033), and the prognostic performance of the CAR was superior to that of C-reactive protein, albumin, and neutrophil to lymphocyte ratio in the receiver operating characteristic curve comparison. CONCLUSION: The CAR, a newly introduced inflammation-based risk index, was found to be a potentially useful prognostic tool for predicting a poor prognosis in STEMI patients. However, this finding needs to be validated in the future prospective studies.
OBJECTIVE: Although the prognostic efficacy of C-reactive protein (mg/L) and albumin levels (g/L) has been previously associated with poor prognosis in ST elevation myocardial infarction (STEMI), to the best of our knowledge, the prognostic efficacy of C-reactive protein/Albumin ratio (CAR) (mg/g) has not been investigated yet. Thus, this study aimed to investigate the potential efficacy of the CAR in predicting prognosis in STEMI patients. METHOD: We conducted a detailed investigation of 2437 patients with first STEMI treated with a primary percutaneous coronary intervention. After evaluation regarding to exclusion criteria, 2243 patients were found to be eligible for analysis. The mean follow-up of the study was 34 ± 15 months. RESULTS: The median CAR value of the study population was 2.70 (range: 1.44-4.76), and the patients were divided into three tertiles according to their CAR values. Kaplan-Meier survival analysis showed significantly lower in-hospital and long-term survival rates for the patients in a high CAR tertile. In addition, the CAR was found to be an independent predictor of all-cause mortality (Hazards ratio: 1.033, 95% Confidence Interval: 1.007-1.061, p = .033), and the prognostic performance of the CAR was superior to that of C-reactive protein, albumin, and neutrophil to lymphocyte ratio in the receiver operating characteristic curve comparison. CONCLUSION: The CAR, a newly introduced inflammation-based risk index, was found to be a potentially useful prognostic tool for predicting a poor prognosis in STEMI patients. However, this finding needs to be validated in the future prospective studies.
Entities:
Keywords:
C-reactive protein to Albumin ratio; ST elevation myocardial infarction; all-cause mortality
Authors: Juana Carretero-Gómez; Pablo Pérez-Martínez; José Miguel Seguí-Ripoll; Francisco Javier Carrasco-Sánchez; Nagore Lois Martínez; Esther Fernández Pérez; Onán Pérez Hernández; Miguel Ángel García Ordoñez; Candelaria Martín González; Juan Francisco Vigueras-Pérez; Francesc Puchades; María Cristina Blasco Avaria; María Isabel Pérez Soto; Javier Ena; José Carlos Arévalo-Lorido Journal: J Clin Med Date: 2022-08-09 Impact factor: 4.964
Authors: Serkan Kahraman; Arda Can Dogan; Gokhan Demirci; Ali Riza Demir; Emre Yilmaz; Hicaz Zencirkiran Agus; Ali Kemal Kalkan; Fatih Uzun; Mehmet Erturk Journal: Braz J Cardiovasc Surg Date: 2020-06-01