| Literature DB >> 30835553 |
Yang-Hua Tang1,2, Ting-Ting Liang2,3, Ting-Ting Fan2, Lawrence Jordan Keen2, Xiao-Dan Zhang2, Lin Xu2, Qi Zhao4, Rong Zeng1, Bing-Nan Han2.
Abstract
Neo-debromoaplysiatoxin C (1), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium Lyngbya sp. The structure of 1 was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCδ activation and inhibitory effects on potassium channel.Entities:
Keywords: Lyngbya sp; Neo-debromoaplysiatoxin C; debromoaplysiatoxin; newly discovered structural frame
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Year: 2019 PMID： 30835553 DOI： 10.1080/14786419.2019.1577840
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861