Esin Yalcinkaya1, Mustafa Mert Basaran2, Hakan Erdem1, Murat Kocyigit3, Aytug Altundag4, Thomas Hummel5. 1. Otorhinolaryngology Department, Medicana International Hospital, Ankara, Turkey. 2. Otorhinolaryngology Department, Ufuk University, Ankara, Turkey. 3. Kanuni Sultan Süleyman Education and Research Hospital, Istanbul, Turkey. 4. Otorhinolaryngology Department, Acibadem Taksim Hospital, Istanbul, Turkey. 5. Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany. thummel@mail.zih.tu-dresden.de.
Abstract
OBJECTIVE: Spondyloarthritis (SpA) is a group of disorders characterized by inflammatory arthritis including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and arthritis-related inflammatory bowel diseases. Recently it has been shown that arthritic disorders are accompanied by olfactory dysfunction. We aimed to specifically investigate the association between spondyloarthritis and olfactory impairment. MATERIALS AND METHODS: Fifty individuals with SpA and 50 healthy volunteers were included in the study. Olfactory function was evaluated using the "Sniffin' Sticks" test battery. Additionally, effects of age, gender, activity of the disease, HLA-B27 status, medications, and the duration of disease were included in the analysis. RESULTS: SpA patients showed significantly lower scores for odor threshold (T), odor discrimination (D) and odor identification (I) than healthy controls (all p < 0.001). In addition, olfactory loss was negatively correlated with the presence of HLA-B27 (Human Leukocyte Antigen), but not with the current activity of the disease (Bath Ankylosing Spondylitis Activity Index). Neither medication nor duration of the disease had a significant effect on the results. CONCLUSION: SpA is associated with olfactory loss. Future studies will show whether olfactory function relates to the prognosis of SpA.
OBJECTIVE:Spondyloarthritis (SpA) is a group of disorders characterized by inflammatory arthritis including ankylosing spondylitis, psoriatic arthritis, reactive arthritis and arthritis-related inflammatory bowel diseases. Recently it has been shown that arthritic disorders are accompanied by olfactory dysfunction. We aimed to specifically investigate the association between spondyloarthritis and olfactory impairment. MATERIALS AND METHODS: Fifty individuals with SpA and 50 healthy volunteers were included in the study. Olfactory function was evaluated using the "Sniffin' Sticks" test battery. Additionally, effects of age, gender, activity of the disease, HLA-B27 status, medications, and the duration of disease were included in the analysis. RESULTS: SpA patients showed significantly lower scores for odor threshold (T), odor discrimination (D) and odor identification (I) than healthy controls (all p < 0.001). In addition, olfactory loss was negatively correlated with the presence of HLA-B27 (Human Leukocyte Antigen), but not with the current activity of the disease (Bath Ankylosing Spondylitis Activity Index). Neither medication nor duration of the disease had a significant effect on the results. CONCLUSION: SpA is associated with olfactory loss. Future studies will show whether olfactory function relates to the prognosis of SpA.
Authors: C Perricone; N Agmon-Levin; N Shoenfeld; C de Carolis; M D Guarino; G Gigliucci; I Milana; L Novelli; G Valesini; R Perricone; Y Shoenfeld Journal: Allergy Date: 2011-01 Impact factor: 13.146
Authors: M A Brown; L G Kennedy; A J MacGregor; C Darke; E Duncan; J L Shatford; A Taylor; A Calin; P Wordsworth Journal: Arthritis Rheum Date: 1997-10
Authors: M Rudwaleit; D van der Heijde; R Landewé; N Akkoc; J Brandt; C T Chou; M Dougados; F Huang; J Gu; Y Kirazli; F Van den Bosch; I Olivieri; E Roussou; S Scarpato; I J Sørensen; R Valle-Oñate; U Weber; J Wei; J Sieper Journal: Ann Rheum Dis Date: 2010-11-24 Impact factor: 19.103