Michelle J Zaso1, Patricia A Goodhines1, Tamara L Wall2,3, Aesoon Park1. 1. Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY, USA. 2. Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA. 3. V.A. San Diego Health System, 3350 La Jolla Village Drive, San Diego, CA, USA.
Abstract
AIMS: The current meta-analysis tested independent and composite associations of three commonly studied alcohol metabolism alleles with alcohol use disorder (AUD) within East Asians as well as characterized potential moderating factors in these associations. METHODS: For meta-analysis, 32 articles were selected that investigated ALDH2 (n = 17,755), ADH1B (n = 13,591) and ADH1C (n = 4,093) associations with AUD in East Asians. RESULTS AND CONCLUSIONS: All three variants were associated with AUD across allelic and genotypic models: ALDH2, ORs = 0.25, P < 0.001; ADH1B, ORs = 0.22-0.49, P < 0.001; ADH1C, ORs = 0.26-0.46, P < 0.001. Composite analyses suggested genetic associations did not differ across ALDH2*2 and ADH1B*2, correcting for multiple comparisons. Moderation analyses suggested ADH1B was more strongly associated with AUD among samples with cases recruited from treatment than the community. Also, strength of ALDH2 and/or ADH1B associations varied with mean age and proportion of men in cases and controls. Findings support medium to large and unique associations of ALDH2, ADH1B, and ADH1C with AUD in East Asians. Results also identified novel methodological and sample characteristics that may modulate strength of these associations.
AIMS: The current meta-analysis tested independent and composite associations of three commonly studied alcohol metabolism alleles with alcohol use disorder (AUD) within East Asians as well as characterized potential moderating factors in these associations. METHODS: For meta-analysis, 32 articles were selected that investigated ALDH2 (n = 17,755), ADH1B (n = 13,591) and ADH1C (n = 4,093) associations with AUD in East Asians. RESULTS AND CONCLUSIONS: All three variants were associated with AUD across allelic and genotypic models: ALDH2, ORs = 0.25, P < 0.001; ADH1B, ORs = 0.22-0.49, P < 0.001; ADH1C, ORs = 0.26-0.46, P < 0.001. Composite analyses suggested genetic associations did not differ across ALDH2*2 and ADH1B*2, correcting for multiple comparisons. Moderation analyses suggested ADH1B was more strongly associated with AUD among samples with cases recruited from treatment than the community. Also, strength of ALDH2 and/or ADH1B associations varied with mean age and proportion of men in cases and controls. Findings support medium to large and unique associations of ALDH2, ADH1B, and ADH1C with AUD in East Asians. Results also identified novel methodological and sample characteristics that may modulate strength of these associations.
Authors: M Osier; A J Pakstis; J R Kidd; J F Lee; S J Yin; H C Ko; H J Edenberg; R B Lu; K K Kidd Journal: Am J Hum Genet Date: 1999-04 Impact factor: 11.025
Authors: João M Castaldelli-Maia; André Malbergier; Adriana B P de Oliveira; Ricardo A Amaral; André B Negrão; Priscila D Gonçalves; Antonio Ventriglio; Domenico de Berardis; Juliana de Antonio; Isabela Firigato; Gilka J F Gattás; Fernanda de Toledo Gonçalves Journal: Biomolecules Date: 2021-10-10