| Literature DB >> 30833792 |
Philipp Hubel1, Christian Urban2, Valter Bergant2, William M Schneider3, Barbara Knauer1, Alexey Stukalov1,2, Pietro Scaturro1,2, Angelika Mann1, Linda Brunotte4,5, Heinrich H Hoffmann3, John W Schoggins3,6, Martin Schwemmle7, Matthias Mann8, Charles M Rice3, Andreas Pichlmair9,10,11.
Abstract
Interferon-stimulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intra- and intercellular viral replication and spread. We conducted a mass-spectrometry-based survey to understand the fundamental organization of the innate immune system and to explore the molecular functions of individual ISGs. We identified interactions between 104 ISGs and 1,401 cellular binding partners engaging in 2,734 high-confidence interactions. 90% of these interactions are unreported so far, and our survey therefore illuminates a far wider activity spectrum of ISGs than is currently known. Integration of the resulting ISG-interaction network with published datasets and functional studies allowed us to identify regulators of immunity and processes related to the immune system. Given the extraordinary robustness of the innate immune system, this ISG network may serve as a blueprint for therapeutic targeting of cellular systems to efficiently fight viral infections.Entities:
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Year: 2019 PMID： 30833792 DOI： 10.1038/s41590-019-0323-3
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 31.250