Mandy Goldberg1, Heba Tawfik2, Jennie Kline3, Karin B Michels4, Ying Wei5, Piera Cirillo6, Barbara A Cohn6, Mary Beth Terry7. 1. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA. 2. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; School of Health Sciences, Walden University, Minneapolis, MN, USA. 3. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; Division of Social Psychiatry, New York State Psychiatric Institute, New York, NY, USA; Gertrude H Sergievsky Center, Columbia University, New York, NY, USA; The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University Mailman School of Public Health, New York, NY, USA. 4. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA; Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Germany. 5. Department of Biostatistics, Columbia University Mailman School of Public Health, New York, NY, USA. 6. The Child Health and Development Studies, Public Health Institute, Berkeley, CA, USA. 7. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA; The Imprints Center for Genetic and Environmental Lifecourse Studies, Columbia University Mailman School of Public Health, New York, NY, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: mt146@columbia.edu.
Abstract
BACKGROUND: Whether birth weight and early-life growth are associated with age at menopause has not been resolved. METHODS: We conducted a prospective study in two U.S. birth cohorts to investigate the relation of weight at birth and weight and growth trajectory through age 4 years to menstrual status among 1001 women ages 39-49 years. We used logistic regression models with GEE. RESULTS: Women who weighed more at birth and at one year were less likely to have experienced the menopausal transition or natural menopause by age 39-49 years (odds ratio(OR) = 0.50, 95% confidence interval(CI) = 0.32, 0.77 and OR = 0.82, 95%CI = 0.68, 0.99 per kilogram increase at birth and age one, respectively). CONCLUSIONS: Women who had a lighter weight at birth and women who were lighter than their peers through infancy experienced the menopausal transition or natural menopause at an earlier age.
BACKGROUND: Whether birth weight and early-life growth are associated with age at menopause has not been resolved. METHODS: We conducted a prospective study in two U.S. birth cohorts to investigate the relation of weight at birth and weight and growth trajectory through age 4 years to menstrual status among 1001 women ages 39-49 years. We used logistic regression models with GEE. RESULTS:Women who weighed more at birth and at one year were less likely to have experienced the menopausal transition or natural menopause by age 39-49 years (odds ratio(OR) = 0.50, 95% confidence interval(CI) = 0.32, 0.77 and OR = 0.82, 95%CI = 0.68, 0.99 per kilogram increase at birth and age one, respectively). CONCLUSIONS:Women who had a lighter weight at birth and women who were lighter than their peers through infancy experienced the menopausal transition or natural menopause at an earlier age.
Authors: Christine R Langton; Brian W Whitcomb; Alexandra C Purdue-Smithe; Lynnette L Sievert; Susan E Hankinson; JoAnn E Manson; Bernard A Rosner; Elizabeth R Bertone-Johnson Journal: Am J Epidemiol Date: 2022-03-24 Impact factor: 5.363