Jamie V de Seymour1, Stephanie Tu1,2, Xiaoling He3, Hua Zhang3, Ting-Li Han1,3, Philip N Baker1,3,4, Karolina Sulek5,6. 1. Liggins Institute, University of Auckland, Auckland, New Zealand. 2. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. 3. Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 4. The College of Life Sciences, University of Leicester, Leicester, UK. 5. Liggins Institute, University of Auckland, Auckland, New Zealand. sulek@sund.ku.dk. 6. Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. sulek@sund.ku.dk.
Abstract
INTRODUCTION: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. OBJECTIVE: Investigate the maternal hair metabolome for predictive biomarkers of ICP. METHODS: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography-mass spectrometry. RESULTS: Of 105 metabolites detected in hair, none were significantly associated with ICP. CONCLUSION: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.
INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. OBJECTIVE: Investigate the maternal hair metabolome for predictive biomarkers of ICP. METHODS: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography-mass spectrometry. RESULTS: Of 105 metabolites detected in hair, none were significantly associated with ICP. CONCLUSION: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.
Entities:
Keywords:
Gas chromatography–mass spectrometry; Hair; Intrahepatic cholestasis of pregnancy; Metabolomics
Authors: Satish C Kalhan; Lining Guo; John Edmison; Srinivasan Dasarathy; Arthur J McCullough; Richard W Hanson; Mike Milburn Journal: Metabolism Date: 2010-04-27 Impact factor: 8.694
Authors: Karolina Sulek; Ting-Li Han; Silas Granato Villas-Boas; David Scott Wishart; Shu-E Soh; Kenneth Kwek; Peter David Gluckman; Yap-Seng Chong; Louise Claire Kenny; Philip Newton Baker Journal: Theranostics Date: 2014-07-20 Impact factor: 11.556