Literature DB >> 30829432

Molecular perturbations in cholangiocarcinoma: Is it time for precision medicine?

Chiara Braconi1,2, Stephanie Roessler3, Beata Kruk4, Frank Lammert5, Marcin Krawczyk4,5, Jesper B Andersen6.   

Abstract

The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome-wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  cholangiocarcinoma; metastasis; precision therapy

Mesh：

Year:  2019        PMID： 30829432     DOI： 10.1111/liv.14085

Source DB:  PubMed          Journal:  Liver Int        ISSN： 1478-3223            Impact factor:   5.828


  7 in total

Review 1.  Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Authors:  Jesus M Banales; Jose J G Marin; Angela Lamarca; Pedro M Rodrigues; Shahid A Khan; Lewis R Roberts; Vincenzo Cardinale; Guido Carpino; Jesper B Andersen; Chiara Braconi; Diego F Calvisi; Maria J Perugorria; Luca Fabris; Luke Boulter; Rocio I R Macias; Eugenio Gaudio; Domenico Alvaro; Sergio A Gradilone; Mario Strazzabosco; Marco Marzioni; Cédric Coulouarn; Laura Fouassier; Chiara Raggi; Pietro Invernizzi; Joachim C Mertens; Anja Moncsek; Sumera Rizvi; Julie Heimbach; Bas Groot Koerkamp; Jordi Bruix; Alejandro Forner; John Bridgewater; Juan W Valle; Gregory J Gores
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-06-30       Impact factor: 46.802

2.  Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis.

Authors:  Stephanie Roessler; Benjamin Goeppert; Alphonse Charbel; Luca Tavernar; Thomas Albrecht; Fritz Brinkmann; Joanne Verheij; Eva Roos; Monika Nadja Vogel; Bruno Köhler; Christoph Springfeld; Alexander Brobeil; Peter Schirmacher; Stephan Singer; Arianeb Mehrabi
Journal:  Br J Cancer       Date:  2022-09-06       Impact factor: 9.075

Review 3.  Current challenges to underpinning the genetic basis for cholangiocarcinoma.

Authors:  Antonio Cigliano; Xin Chen; Diego F Calvisi
Journal:  Expert Rev Gastroenterol Hepatol       Date:  2021-04-23       Impact factor: 3.869

Review 4.  Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology.

Authors:  Enrico Gringeri; Martina Gambato; Gonzalo Sapisochin; Tommy Ivanics; Erica Nicola Lynch; Claudia Mescoli; Patrizia Burra; Umberto Cillo; Francesco Paolo Russo
Journal:  J Clin Med       Date:  2020-05-05       Impact factor: 4.241

5.  Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+ Cells.

Authors:  Pietro Carotenuto; Somaieh Hedayat; Matteo Fassan; Vincenzo Cardinale; Andrea Lampis; Vincenza Guzzardo; Caterina Vicentini; Aldo Scarpa; Luciano Cascione; Daniele Costantini; Guido Carpino; Domenico Alvaro; Michele Ghidini; Francesco Trevisani; Robert Te Poele; Massimiliano Salati; Sofia Ventura; Georgios Vlachogiannis; Jens C Hahne; Luke Boulter; Stuart J Forbes; Rachel V Guest; Umberto Cillo; Ian Said-Huntingford; Ruwaida Begum; Elizabeth Smyth; Vasiliki Michalarea; David Cunningham; Lorenza Rimassa; Armando Santoro; Massimo Roncalli; Vladimir Kirkin; Paul Clarke; Paul Workman; Nicola Valeri; Chiara Braconi
Journal:  Hepatology       Date:  2020-09-10       Impact factor: 17.425

Review 6.  Prognostic and Predictive Molecular Markers in Cholangiocarcinoma.

Authors:  Sandra Pavicevic; Sophie Reichelt; Deniz Uluk; Isabella Lurje; Cornelius Engelmann; Dominik P Modest; Uwe Pelzer; Felix Krenzien; Nathanael Raschzok; Christian Benzing; Igor M Sauer; Sebastian Stintzing; Frank Tacke; Wenzel Schöning; Moritz Schmelzle; Johann Pratschke; Georg Lurje
Journal:  Cancers (Basel)       Date:  2022-02-17       Impact factor: 6.639

Review 7.  Current and novel therapeutic opportunities for systemic therapy in biliary cancer.

Authors:  José J G Marin; Maria Giuseppina Prete; Angela Lamarca; Simona Tavolari; Ana Landa-Magdalena; Giovanni Brandi; Oreste Segatto; Arndt Vogel; Rocío I R Macias; Pedro M Rodrigues; Adelaida La Casta; Joachim Mertens; Cecilia M P Rodrigues; Maite G Fernandez-Barrena; Ana Da Silva Ruivo; Marco Marzioni; Giulia Mentrasti; Pilar Acedo; Patricia Munoz-Garrido; Vincenzo Cardinale; Jesus M Banales; Juan W Valle; John Bridgewater; Chiara Braconi
Journal:  Br J Cancer       Date:  2020-07-22       Impact factor: 7.640
  7 in total

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