Literature DB >> 3082932

Monoclonal antibodies that distinguish between normal and denervated human acetylcholine receptor.

P J Whiting, A Vincent, M Schluep, J Newsom-Davis.   

Abstract

Ten monoclonal anti-human acetylcholine receptor (AChR) monoclonal antibodies (m.abs) all exhibited high avidity binding to the human AChR. None was able to inhibit alpha-bungarotoxin (alpha-Butx) binding to the receptor. Five distinct but partially overlapping antibody-binding regions were defined by competition experiments. Four antibodies, which competed with each other for one region on denervated human AChR and also bound to human fetal AChR, failed to bind appreciably to normal human AChR in solution, to normal AChR solubilized from 6 other species, or to human endplates in frozen sections.

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Year:  1986        PMID： 3082932     DOI： 10.1016/0165-5728(86)90006-8

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

1.  A comparison of MyoD1 and fetal acetylcholine receptor expression in childhood tumors and normal tissues: implications for the molecular diagnosis of minimal disease in rhabdomyosarcomas.

Authors:  S Gattenloehner; B Dockhorn-Dworniczak; I Leuschner; A Vincent; H K Müller-Hermelink; A Marx
Journal:  J Mol Diagn       Date:  1999-11       Impact factor: 5.568

2.  Chimaeric monoclonal antibodies encoded by the human VH26 gene from naïve transgenic mice display a wide range of antigen-binding specificities.

Authors:  I J Harmer; R A Mageed; A Kaminski; P Charles; M Brüggemann; C G Mackworth-Young
Journal:  Immunology       Date:  1996-06       Impact factor: 7.397

Review 3.  Myasthenia gravis: an autoimmune response against the acetylcholine receptor.

Authors:  Y M Graus; M H De Baets
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

4.  The fetal form of the acetylcholine receptor distinguishes rhabdomyosarcomas from other childhood tumors.

Authors:  S Gattenloehner; A Vincent; I Leuschner; S Tzartos; H K Müller-Hermelink; T Kirchner; A Marx
Journal:  Am J Pathol       Date:  1998-02       Impact factor: 4.307

5.  Action of antibodies directed against the acetylcholine receptor on channel function at mouse and rat motor end-plates.

Authors:  J O Dolly; M Gwilt; G Lacey; J Newsom-Davis; A Vincent; P Whiting; D W Wray
Journal:  J Physiol       Date:  1988-05       Impact factor: 5.182

6.  Functional and non-functional isoforms of the human muscle acetylcholine receptor.

Authors:  C F Newland; D Beeson; A Vincent; J Newsom-Davis
Journal:  J Physiol       Date:  1995-12-15       Impact factor: 5.182

7.  Association of arthrogryposis multiplex congenita with maternal antibodies inhibiting fetal acetylcholine receptor function.

Authors:  S Riemersma; A Vincent; D Beeson; C Newland; S Hawke; B Vernet-der Garabedian; B Eymard; J Newsom-Davis
Journal:  J Clin Invest       Date:  1996-11-15       Impact factor: 14.808

8.  Association between autonomic nervous dysfunction and cellular inflammation in end-stage renal disease.

Authors:  Eric Seibert; Kristina Zohles; Christof Ulrich; Alexander Kluttig; Sebastian Nuding; Jan A Kors; Cees A Swenne; Karl Werdan; Roman Fiedler; Matthias Girndt
Journal:  BMC Cardiovasc Disord       Date:  2016-11-03       Impact factor: 2.298

Review 9.  The Structure, Function, and Physiology of the Fetal and Adult Acetylcholine Receptor in Muscle.

Authors:  Hakan Cetin; David Beeson; Angela Vincent; Richard Webster
Journal:  Front Mol Neurosci       Date:  2020-09-08       Impact factor: 5.639
  9 in total

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