Literature DB >> 30829300

Role of laboratory markers in predicting severity of acute appendicitis.

Samarth Virmani1, Padubidri Santosh Prabhu1, P T Sundeep1, Vijay Kumar1.   

Abstract

MATERIALS AND METHODS: Record of 233 patients under 18 years of age who underwent appendectomy from 2005 to 2014 was evaluated. Based on perioperative findings of the surgeon, the patients were grouped under categories simple acute appendicitis (SAA) and CAA. Information such as age, gender, and laboratory investigations of the patients were recorded and analyzed.
BACKGROUND: Accurately differentiating simple and complicated acute appendicitis (CAA) in children preoperatively can be challenging. The aim of this study is to evaluate the ability of the neutrophil-to-lymphocyte ratio (NLR), total leukocyte count (TLC), percentage lymphocyte, and percentage neutrophil counts to predict the type of appendicitis a patient has preoperatively and to determine the better indicator among these.
RESULTS: SAA included 185 patients and CAA included 48 patients. An NLR >4.8, TLC >13,500 cells/mm3, percentage lymphocyte count <14.8%, and percentage neutrophil count >75% were found to be associated with complicated appendicitis. The highest sensitivity and specificity among these findings were found with the percentage lymphocyte count, which were 70.8% and 63.8%, respectively.
CONCLUSION: The preoperative percentage lymphocyte count serves as a better indicator than TLC, NLR, and percentage lymphocyte count and is a useful parameter in differentiating simple and complicated appendicitis and can be used as a valuable adjunct to the surgeon's clinical evaluation.

Entities:  

Keywords:  Appendicitis; lymphocyte; neutrophil

Mesh:

Substances:

Year:  2018        PMID: 30829300      PMCID: PMC6419549          DOI: 10.4103/ajps.AJPS_47_16

Source DB:  PubMed          Journal:  Afr J Paediatr Surg        ISSN: 0974-5998


  18 in total

1.  Neutrophil/lymphocyte ratio in the diagnosis of childhood appendicitis.

Authors:  Mesut Yazici; Sezen Ozkisacik; M Onur Oztan; Harun Gürsoy
Journal:  Turk J Pediatr       Date:  2010 Jul-Aug       Impact factor: 0.552

2.  Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children.

Authors:  Lilia Lycopoulou; Charalambos Mamoulakis; Eugenia Hantzi; Dimitrios Demetriadis; Spyros Antypas; Maria Giannaki; Chryssa Bakoula; George Chrousos; Ioannis Papassotiriou
Journal:  Clin Chem Lab Med       Date:  2005       Impact factor: 3.694

3.  How time affects the risk of rupture in appendicitis.

Authors:  Nina A Bickell; Arthur H Aufses; Mary Rojas; Carol Bodian
Journal:  J Am Coll Surg       Date:  2006-01-18       Impact factor: 6.113

4.  The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis.

Authors:  S R Markar; A Karthikesalingam; A Falzon; Y Kan
Journal:  Acta Chir Belg       Date:  2010 Sep-Oct       Impact factor: 1.090

5.  Validity of leukocyte count to predict the severity of acute appendicitis.

Authors:  Salman Y Guraya; Talal A Al-Tuwaijri; Gamal A Khairy; Khalid R Murshid
Journal:  Saudi Med J       Date:  2005-12       Impact factor: 1.484

6.  Laboratory tests in patients with acute appendicitis.

Authors:  Horng-Ren Yang; Yu-Chun Wang; Ping-Kuei Chung; Wei-Kung Chen; Long-Bin Jeng; Ray-Jade Chen
Journal:  ANZ J Surg       Date:  2006 Jan-Feb       Impact factor: 1.872

7.  Plasma D-lactate levels in diagnosis of appendicitis.

Authors:  Fatma Cağlayan; Murat Cakmak; Osman Cağlayan; Turgut Cavuşoglu
Journal:  J Invest Surg       Date:  2003 Jul-Aug       Impact factor: 2.533

Review 8.  Meta-analysis of the clinical and laboratory diagnosis of appendicitis.

Authors:  R E B Andersson
Journal:  Br J Surg       Date:  2004-01       Impact factor: 6.939

9.  Inflammatory markers for acute appendicitis in children: are they helpful?

Authors:  Giorgio Stefanutti; Vittorina Ghirardo; Piergiorgio Gamba
Journal:  J Pediatr Surg       Date:  2007-05       Impact factor: 2.545

10.  Diagnostic Value of C-reactive Protein in Complicated Appendicitis.

Authors:  Hyoung-Min Moon; Beom-Seok Park; Duk-Jin Moon
Journal:  J Korean Soc Coloproctol       Date:  2011-06-30
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Journal:  Pak J Med Sci       Date:  2021 Mar-Apr       Impact factor: 1.088

Review 2.  Related Markers for the Precision Diagnosis of Complex Appendicitis in Children.

Authors:  Jialin Zhou; Wenjing Xu; Jitao Wang; Zhe Fan
Journal:  Front Pharmacol       Date:  2022-03-31       Impact factor: 5.988

3.  Serum Soluble CD40 Ligand in Predicting Simple Appendicitis and Complicated Appendicitis at Different Time Points in Children.

Authors:  Wun-Yan Huang; Chun-Yu Chen; Yu-Jun Chang; En-Pei Lee; Han-Ping Wu
Journal:  Front Pediatr       Date:  2021-06-09       Impact factor: 3.418

  3 in total

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