| Literature DB >> 30829043 |
Xiao-Bing Huang1, Xian-Jing Li1, Tian-Tian Li1, Bo Chen1, Wen-Dao Chu1, Long He1,2, Quan-Zhong Liu1.
Abstract
Palladium-catalyzed asymmetric formal [3 + 2] cycloaddition of vinyl cyclopropanes and aldimines or isatin-derived ketimines proceeded smoothly in the presence of chiral phosphoramidite ligands. The corresponding highly functionalized and optically enriched pyrrolidine or spiro[pyrrolidin-3,2'-oxindole] derivatives are obtained in up to 94% yield and with up to 96% ee and 7:1 dr.Entities:
Year: 2019 PMID： 30829043 DOI： 10.1021/acs.orglett.9b00274
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005