Samir Arbache1, Elizabeth da Costa Mattos2, Milton F Diniz2, Pedro Y A Paiva3, Dirlene Roth4, Samia T Arbache5, Edna L T Oliveira6, Nilceo S Michalany7, Sergio H Hirata8. 1. Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil. 2. Department of Aerospace Science and Technology - DCTA Aeronautics and Space Institute - IAE, Department of Chemistry, São José dos Campos/SP, Brazil. 3. Department of Computer Science, Aeronautical Technology Institute, São José dos Campos/SP, Brazil. 4. Private practice, São Paulo, Brazil. 5. Faculdade de Medicina do ABC, Santo André, Brazil. 6. Pharmacist of Farmácia de Manipulação Terapêutica, São José dos Campos/SP, Brazil. 7. Department of Pathology, São Paulo State School of Medicine, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil. 8. Department of Dermatology, São Paulo State School of Medicine, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil.
Abstract
BACKGROUND: Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. OBJECTIVE: Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. METHODS: Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. RESULTS: In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm2 , and a needling depth of 300 microns, we estimate that 1,175 μg/cm2 were delivered (standard deviation 601 μg/cm2 , standard error 190 μg/cm2 ). LIMITATIONS: This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. CONCLUSION: The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm2 ) homogeneously into the dermis.
BACKGROUND: Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. OBJECTIVE: Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. METHODS: Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. RESULTS: In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm2 , and a needling depth of 300 microns, we estimate that 1,175 μg/cm2 were delivered (standard deviation 601 μg/cm2 , standard error 190 μg/cm2 ). LIMITATIONS: This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. CONCLUSION: The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm2 ) homogeneously into the dermis.