Effects of glycerol on 4-nitroquinoline 1-oxide induced pulmonary tumorigenesis in ddY mice.

The effects of glycerol administration on pulmonary tumorigenesis induced by 4-nitroquinoline 1-oxide (4NQO) were examined in male ddY mice, that were given 5% glycerol solution instead of drinking water after a subcutaneous injection of 4NQO. The incidence of pulmonary tumor-bearing mice and the mean number of induced tumors per mouse were significantly enhanced in mice given glycerol after 4NQO treatment, compared with mice given 4NQO alone. The results demonstrate effects including that of promotion by glycerol in 4NQO-induced pulmonary tumorigenesis.