Literature DB >> 3082811

Sodium citrate: a promoter of bladder carcinogenesis.

S Fukushima, W Thamavit, Y Kurata, N Ito.   

Abstract

Dietary administration of 5% sodium citrate to male F344 rats clearly promoted the induction of preneoplastic and neoplastic lesions of the bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Enhancement of tumorigenesis by sodium citrate was associated with changes in a number of urinary parameters: apparent elevation of pH; increase of sodium ion concentration; increase of crystalline MgNH4PO4. These results show that sodium citrate promotes bladder carcinogenesis.

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Year:  1986        PMID： 3082811

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  6 in total

1.  Evolution on experimental animal model for upper urothelium carcinogenesis.

Authors:  Leonardo O Reis; Wagner J Fávaro; Ubirajara Ferreira; Athanase Billis; Mariana G Fazuoli; Valéria H A Cagnon
Journal:  World J Urol       Date:  2010-04-06       Impact factor: 4.226

2.  Chemical carcinogenesis of the urinary bladder--a status report.

Authors:  R F Jones; M Debiec-Rychter; C Y Wang
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

3.  Strain differences in sensitivity to the promoting effect of sodium L-ascorbate in a two-stage rat urinary bladder carcinogenesis model.

Authors:  T Murai; S Mori; M Hosono; A Takashima; S Machino; T Oohara; H Yamashita; S Makino; T Matsuda; H Wanibuchi; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1997-03

4.  Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.

Authors:  Y Kurata; S Fukushima; R Hasegawa; M Hirose; M Shibata; T Shirai; N Ito
Journal:  Jpn J Cancer Res       Date:  1990-08

5.  Synergism of environmental carcinogens and promoters on bladder cancer development initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine in F344 rats.

Authors:  S Ono; Y Kurata; Y Shichino; M Sano; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1992-09

6.  Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Authors:  J L de Camargo; T Shirai; T Kato; M Asamoto; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1991-11
  6 in total

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