Jun Seok Son1, Song Ah Chae2, Byung Ik Park3, Min Du4, Wook Song5. 1. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA; Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, Seoul 08826, South Korea. 2. Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, Seoul 08826, South Korea; Department of Movement Sciences, University of Idaho, Moscow, ID 83844, USA. 3. School of Public Health, Indiana University, Bloomington, IN 47405, USA. 4. Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA. Electronic address: min.du@wsu.edu. 5. Health and Exercise Science Laboratory, Institute of Sport Science, Seoul National University, Seoul 08826, South Korea; Institute on Aging, Seoul National University, South Korea. Electronic address: songw3@snu.ac.kr.
Abstract
INTRODUCTION: Physical activity is beneficial for preventing metabolic diseases. Here, the circulatory level of apelin, one of the myokines, was assessed in patients with obesity to examine the effects of body composition, metabolic parameters, and physical fitness on apelin secretion following an exercise program. METHODS: A total 60 subjects [34 women (21 lean and 13 overweight/obese) and 26 men (8 lean and 18 overweight/obese)], age 30-59 years, with body mass index (BMI) of 18-30kg/m2 were recruited based on the guidelines for Korean obesity therapy in a clinical trial. Body composition, biochemical parameters, and physical fitness test were conducted. A single bout of exhaustive exercise was performed following Bruce protocol. Relationships among exercise-induced apelin, metabolic factors, and physical capacity were then analyzed. Independent/paired t-test between groups/time points and Pearson correlations were performed. RESULTS: There were significant positive correlations in post-exercise apelin and lean mass (P=0.006), homeostatic model assessment of insulin resistance (HOMA-IR; P=0.004), HOMA insulin secretion (HOMA-%B; P=0.005), lactate dehydrogenase (LDH; P=0.002), grip strength (P=0.004), and isokinetic knee flexion and extension tests in 60° and 240°/s (all variables, P<0.05), but these parameters were not correlated with pre-exercise apelin. Exercise was more effective in increasing apelin level in men compared to women. CONCLUSION: Acute exercise increased circulating apelin, which was more effective in obese compared to healthy men, while no effect in women regardless of obesity status. Thus, apelin secretion after a single exercise is dependent on gender and metabolic status of subjects.
INTRODUCTION: Physical activity is beneficial for preventing metabolic diseases. Here, the circulatory level of apelin, one of the myokines, was assessed in patients with obesity to examine the effects of body composition, metabolic parameters, and physical fitness on apelin secretion following an exercise program. METHODS: A total 60 subjects [34 women (21 lean and 13 overweight/obese) and 26 men (8 lean and 18 overweight/obese)], age 30-59 years, with body mass index (BMI) of 18-30kg/m2 were recruited based on the guidelines for Korean obesity therapy in a clinical trial. Body composition, biochemical parameters, and physical fitness test were conducted. A single bout of exhaustive exercise was performed following Bruce protocol. Relationships among exercise-induced apelin, metabolic factors, and physical capacity were then analyzed. Independent/paired t-test between groups/time points and Pearson correlations were performed. RESULTS: There were significant positive correlations in post-exercise apelin and lean mass (P=0.006), homeostatic model assessment of insulin resistance (HOMA-IR; P=0.004), HOMA insulin secretion (HOMA-%B; P=0.005), lactate dehydrogenase (LDH; P=0.002), grip strength (P=0.004), and isokinetic knee flexion and extension tests in 60° and 240°/s (all variables, P<0.05), but these parameters were not correlated with pre-exercise apelin. Exercise was more effective in increasing apelin level in men compared to women. CONCLUSION: Acute exercise increased circulating apelin, which was more effective in obese compared to healthy men, while no effect in women regardless of obesity status. Thus, apelin secretion after a single exercise is dependent on gender and metabolic status of subjects.
Keywords:
Clinical trials; Ensayos clínicos; Insulin resistance; Insulin secretion; Mioquinas; Myokines; Obesity treatment; Resistencia a la insulina; Secreción de insulina; Tratamiento de la obesidad
Authors: Il-Young Jang; Seungjoo Lee; Jeoung Hee Kim; Eunju Lee; Jin Young Lee; So Jeong Park; Da Ae Kim; Mark W Hamrick; Jin Hoon Park; Beom-Jun Kim Journal: BMC Geriatr Date: 2020-10-21 Impact factor: 3.921