Cherif Dial1, Kwame Doh2, Ibou Thiam3, Romulus Carmen Adechina Takin4, Paule Aïda Ndoye Roth5, Claude Moreira6, Gisèle Wotogaye7. 1. Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital de Grand Yoff, Dakar, Sénégal. Electronic address: dialcherif@yahoo.fr. 2. Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital Aristide le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal. Electronic address: kwame.doh@ucad.edu.sn. 3. Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital Aristide le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal. Electronic address: dribouthiam@yahoo.fr. 4. Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital de Grand Yoff, Dakar, Sénégal. Electronic address: rtakin@yahoo.fr. 5. Service d'ophtalmologie de l'hôpital Aristide le Dantec, avenue Pasteur, BP 3001, Dakar, Sénégal. 6. Service d'oncologie pédiatrique de l'hôpital Aristide le Dantec, avenue Pasteur, BP 3001, Dakar, Sénégal. 7. Laboratoire d'anatomie et de cytologie pathologiques de l'hôpital Aristide le Dantec, pavillon Bichat, avenue Pasteur, BP 3001, Dakar, Sénégal. Electronic address: giselewotogaye@yahoo.fr.
Abstract
OBJECTIVES: Describe the macroscopic and microscopic profiles of the retinoblastoma (RB) in Senegal and correlate histological criteria to evolution to emerge severity factors. METHODOLOGY: We realized a retrospective study on 10years (January 2005-December 2014). Only patients (n=67) who performed a histological analysis of the enucleation specimen (n=68) were followed until the end of the study. RESULTS: The tumor measured an average of 3.8cm (2/4.5). Endophytic tumor development was in 55 cases (80.8%), exophytic in 6 cases (8.9%) and mixed in 7 cases (10.3%). Extra-retinal form was present in 13 cases (19.2%). The RB was well differentiated in 11 cases (16.2%), moderately differentiated in 31 cases (45.6%) and undifferentiated in 26 cases. The invasion of optic nerve (ON) was present in 18 cases (26.5%). The tumor was extra-retinal in 37 cases (54.4%). The anterior chamber was invaded in 6 cases (8.8%). The global survival at 2years was 84% and 70% at 5years. In multivariate analysis, well tumor differentiation and stage pT1 were associated with remission. The other-laminar of ON invasion, the massive invasion of the choroid and pT3 stage were recurrence risk factors. The undifferentiating tumor, invasion of the ON section, tumor sclera crossing and pT4 stage were predictive death. CONCLUSION: The RB histological prognostic factors should be clearly identified in the pathological reports as they guide the after surgical period care and follow-up management strategy.
OBJECTIVES: Describe the macroscopic and microscopic profiles of the retinoblastoma (RB) in Senegal and correlate histological criteria to evolution to emerge severity factors. METHODOLOGY: We realized a retrospective study on 10years (January 2005-December 2014). Only patients (n=67) who performed a histological analysis of the enucleation specimen (n=68) were followed until the end of the study. RESULTS: The tumor measured an average of 3.8cm (2/4.5). Endophytic tumor development was in 55 cases (80.8%), exophytic in 6 cases (8.9%) and mixed in 7 cases (10.3%). Extra-retinal form was present in 13 cases (19.2%). The RB was well differentiated in 11 cases (16.2%), moderately differentiated in 31 cases (45.6%) and undifferentiated in 26 cases. The invasion of optic nerve (ON) was present in 18 cases (26.5%). The tumor was extra-retinal in 37 cases (54.4%). The anterior chamber was invaded in 6 cases (8.8%). The global survival at 2years was 84% and 70% at 5years. In multivariate analysis, well tumor differentiation and stage pT1 were associated with remission. The other-laminar of ON invasion, the massive invasion of the choroid and pT3 stage were recurrence risk factors. The undifferentiating tumor, invasion of the ON section, tumor sclera crossing and pT4 stage were predictive death. CONCLUSION: The RB histological prognostic factors should be clearly identified in the pathological reports as they guide the after surgical period care and follow-up management strategy.