Literature DB >> 30827673

E3 ubiquitin ligases in B-cell malignancies.

Jaewoo Choi1, Luca Busino2.   

Abstract

Ubiquitylation is a post-translational modification (PTM) that controls various cellular signaling pathways. It is orchestrated by a three-step enzymatic cascade know as the ubiquitin proteasome system (UPS). E3 ligases dictate the specificity to the substrates, primarily leading to proteasome-dependent degradation. Deregulation of the UPS components by various mechanisms contributes to the pathogenesis of cancer. This review focuses on E3 ligase-substrates pairings that are implicated in B-cell malignancies. Understanding the molecular mechanism of specific E3 ubiquitin ligases will present potential opportunities for the development of targeted therapeutic approaches.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2019        PMID： 30827673      PMCID： PMC6584052          DOI： 10.1016/j.cellimm.2019.02.004

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


  143 in total

1.  Pellino-related sequences from Caenorhabditis elegans and Homo sapiens.

Authors:  T Rich; R L Allen; A M Lucas; A Stewart; J Trowsdale
Journal:  Immunogenetics       Date:  2000-11       Impact factor: 2.846

2.  RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

Authors:  K L Lorick; J P Jensen; S Fang; A M Ong; S Hatakeyama; A M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-28       Impact factor: 11.205

3.  Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.

Authors:  L Deng; C Wang; E Spencer; L Yang; A Braun; J You; C Slaughter; C Pickart; Z J Chen
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

4.  Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

Authors:  P Kavsak; R K Rasmussen; C G Causing; S Bonni; H Zhu; G H Thomsen; J L Wrana
Journal:  Mol Cell       Date:  2000-12       Impact factor: 17.970

5.  Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.

Authors:  X Lin; M Liang; X H Feng
Journal:  J Biol Chem       Date:  2000-11-24       Impact factor: 5.157

6.  Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs.

Authors:  M J Callaghan; A J Russell; E Woollatt; G R Sutherland; R L Sutherland; C K Watts
Journal:  Oncogene       Date:  1998-12-31       Impact factor: 9.867

7.  The base of the proteasome regulatory particle exhibits chaperone-like activity.

Authors:  B C Braun; M Glickman; R Kraft; B Dahlmann; P M Kloetzel; D Finley; M Schmidt
Journal:  Nat Cell Biol       Date:  1999-08       Impact factor: 28.824

8.  c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.

Authors:  F Bahram; N von der Lehr; C Cetinkaya; L G Larsson
Journal:  Blood       Date:  2000-03-15       Impact factor: 22.113

9.  Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

Authors:  L Huang; E Kinnucan; G Wang; S Beaudenon; P M Howley; J M Huibregtse; N P Pavletich
Journal:  Science       Date:  1999-11-12       Impact factor: 47.728

10.  Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis.

Authors:  N Kishi; Z Tang; Y Maeda; A Hirai; R Mo; M Ito; S Suzuki; K Nakao; T Kinoshita; T Kadesch; C Hui; S Artavanis-Tsakonas; H Okano; K Matsuno
Journal:  Int J Dev Neurosci       Date:  2001-02       Impact factor: 2.457
View more
  1 in total

1.  Special Issue: E3 ubiquitin ligases, the match makers and grim reapers of immune cells.

Authors:  Emily Moser; Paula M Oliver
Journal:  Cell Immunol       Date:  2019-05-10       Impact factor: 4.868
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.