Ryosuke Takegawa1, Daijiro Kabata2, Kentaro Shimizu3, Saya Hisano4, Hiroshi Ogura5, Ayumi Shintani4, Takeshi Shimazu6. 1. Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: r-takegawa@hp-emerg.med.osaka-u.ac.jp. 2. Department of Medical Statistics, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-cho, Abeno-ku, Osaka city, Osaka 545-0051, Japan. Electronic address: kabata.daijiro@med.osaka-cu.ac.jp. 3. Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: shimiken@hp-emerg.med.osaka-u.ac.jp. 4. Department of Medical Statistics, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-cho, Abeno-ku, Osaka city, Osaka 545-0051, Japan. 5. Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: ogura@hp-emerg.med.osaka-u.ac.jp. 6. Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-oka, Suita, Osaka 565-0871, Japan. Electronic address: shimazu@hp-emerg.med.osaka-u.ac.jp.
Abstract
PURPOSE: The aim of this study was to evaluate an association between nutritional biomarkers and prognosis in septic patients. METHODS: We retrospectively searched the association between nutritional biomarkers including serum albumin (Alb), total protein (TP), total cholesterol (T-chol), and cholinesterase (ChE), and prognosis for septic patients treated in the ICU for >7 days. We used time-dependent Cox proportional hazard regression analysis to resolve the difference of the statistical weight of each day's data for all 14 consecutive days among individual sepsis patients. The covariates were based on the minimum moving values determined from 1 day, 3 days, 7 days, and 14 days of serial data. The values of these covariates and ICU survival were considered as outcomes. RESULTS: We included 136 septic patients. The decreases in the values of Alb, TP, T-chol, and ChE were significantly associated with the risk of death in the septic patients (p < .05). Especially, the daily changes of Alb were significantly associated with mortality during the ICU stay (p < .05). CONCLUSIONS: We found that the changes in serial data of the nutritional markers of Alb, TP, T-chol, and ChE reflected the higher risk of death in patients with prolonged sepsis.
PURPOSE: The aim of this study was to evaluate an association between nutritional biomarkers and prognosis in septic patients. METHODS: We retrospectively searched the association between nutritional biomarkers including serum albumin (Alb), total protein (TP), total cholesterol (T-chol), and cholinesterase (ChE), and prognosis for septic patients treated in the ICU for >7 days. We used time-dependent Cox proportional hazard regression analysis to resolve the difference of the statistical weight of each day's data for all 14 consecutive days among individual sepsispatients. The covariates were based on the minimum moving values determined from 1 day, 3 days, 7 days, and 14 days of serial data. The values of these covariates and ICU survival were considered as outcomes. RESULTS: We included 136 septic patients. The decreases in the values of Alb, TP, T-chol, and ChE were significantly associated with the risk of death in the septicpatients (p < .05). Especially, the daily changes of Alb were significantly associated with mortality during the ICU stay (p < .05). CONCLUSIONS: We found that the changes in serial data of the nutritional markers of Alb, TP, T-chol, and ChE reflected the higher risk of death in patients with prolonged sepsis.
Authors: Aiyang A Jiang; Holly S Greenwald; Lamiya Sheikh; Darcy A Wooten; Atul Malhotra; Robert T Schooley; Daniel A Sweeney Journal: Open Forum Infect Dis Date: 2019-11-05 Impact factor: 3.835
Authors: Olivier Ballo; Fagr Eladly; Stefan Büttner; Jan Alexander Stratmann; Sarah Rudolf; Uta Brunnberg; Eva-Maria Kreisel; Björn Steffen; Sebastian Wagner; Fabian Finkelmeier; Hubert Serve; Christian H Brandts Journal: Ann Hematol Date: 2021-03-11 Impact factor: 3.673
Authors: Eyal Klang; Shelly Soffer; Eyal Zimlichman; Alexis Zebrowski; Benjamin S Glicksberg; E Grossman; David L Reich; Robert Freeman; Matthew A Levin Journal: BMJ Open Date: 2021-10-27 Impact factor: 3.006