Isaac H Solomon1,2, William P Docken1,2, Robert F Padera3,4. 1. From the Department of Pathology, and Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. 2. I.H. Solomon, MD, PhD, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School; W.P. Docken, MD, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; R.F. Padera Jr., MD, PhD, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School. 3. From the Department of Pathology, and Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. rpadera@bwh.harvard.edu. 4. I.H. Solomon, MD, PhD, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School; W.P. Docken, MD, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; R.F. Padera Jr., MD, PhD, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School. rpadera@bwh.harvard.edu.
Abstract
OBJECTIVE: A variety of infectious agents, including varicella zoster virus (VZV), have been hypothesized to play a role in the pathogenesis of giant cell arteritis (GCA). The detectability of the virus in patients with GCA is debatable. To further investigate an association between GCA and VZV infection, 10 years of GCA cases were evaluated for VZV by immunohistochemistry (IHC). METHODS: All temporal artery biopsies and ascending aortic resections positive for GCA from 2007 to 2017 at Brigham and Women's Hospital were immunostained using a VZV antibody cocktail (SG1-1, SG1-SG4, NCP-1, and IE-62). RESULTS: Forty-one temporal artery biopsies and 47 ascending aortic resections positive for GCA were identified, all of which were found to be negative for VZV by IHC. Twelve temporal artery biopsies in this cohort were previously analyzed by unbiased metagenomics sequencing and were negative for VZV DNA. CONCLUSION: These results argue against a clinically relevant association between VZV infection and GCA, and support neither routine testing for VZV nor treatment with antiviral drugs.
OBJECTIVE: A variety of infectious agents, including varicella zoster virus (VZV), have been hypothesized to play a role in the pathogenesis of giant cell arteritis (GCA). The detectability of the virus in patients with GCA is debatable. To further investigate an association between GCA and VZV infection, 10 years of GCA cases were evaluated for VZV by immunohistochemistry (IHC). METHODS: All temporal artery biopsies and ascending aortic resections positive for GCA from 2007 to 2017 at Brigham and Women's Hospital were immunostained using a VZV antibody cocktail (SG1-1, SG1-SG4, NCP-1, and IE-62). RESULTS: Forty-one temporal artery biopsies and 47 ascending aortic resections positive for GCA were identified, all of which were found to be negative for VZV by IHC. Twelve temporal artery biopsies in this cohort were previously analyzed by unbiased metagenomics sequencing and were negative for VZV DNA. CONCLUSION: These results argue against a clinically relevant association between VZV infection and GCA, and support neither routine testing for VZV nor treatment with antiviral drugs.
Authors: Robert M Verdijk; Werner J D Ouwendijk; Robert W A M Kuijpers; Georges M G M Verjans Journal: J Infect Dis Date: 2021-01-04 Impact factor: 5.226
Authors: Andrew N Bubak; Teresa Mescher; Michael Mariani; Seth E Frietze; James E Hassell; Christy S Niemeyer; Christina N Como; Anna M Burnet; Prem S Subramanian; Randall J Cohrs; Ravi Mahalingam; Maria A Nagel Journal: Neurol Neuroimmunol Neuroinflamm Date: 2021-09-07