G Petringa1, F Romano2, L Manti3, L Pandola4, A Attili5, F Cammarata6, G Cuttone4, G Forte6, L Manganaro5, J Pipek7, P Pisciotta1, G Russo6, G A P Cirrone8. 1. INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; Dipartimento di Fisica e Astronomia, Universitá degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy. 2. INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; National Physical Laboratory, Acoustic and Ionizing Radiation Division, Teddington TW11 0LW, Middlesex, UK. 3. Dipartimento di Fisica E. Pancini, Universitá degli Studi Federico II di Napoli, Via Cinthia, I-80126 Napoli, Italy; INFN-NA, Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Complesso Universitario di M. S. Angelo, Via Cintia, I-80126 Napoli, Italy. 4. INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy. 5. INFN-TO, Istituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy. 6. INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; IBFM-CNR, Institute of Molecular Bioimaging and Physiology - National Research Council, Cefalù, PA, Italy. 7. ELI-Beamline Project, Inst. Physics, ASCR, PALS Center, Prague, Czech Republic. 8. INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; ELI-Beamline Project, Inst. Physics, ASCR, PALS Center, Prague, Czech Republic. Electronic address: pablo.cirrone@lns.infn.it.
Abstract
PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines. Crown
PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines. Crown
Authors: P Arce; D Bolst; M-C Bordage; J M C Brown; P Cirrone; M A Cortés-Giraldo; D Cutajar; G Cuttone; L Desorgher; P Dondero; A Dotti; B Faddegon; C Fedon; S Guatelli; S Incerti; V Ivanchenko; D Konstantinov; I Kyriakou; G Latyshev; A Le; C Mancini-Terracciano; M Maire; A Mantero; M Novak; C Omachi; L Pandola; A Perales; Y Perrot; G Petringa; J M Quesada; J Ramos-Méndez; F Romano; A B Rosenfeld; L G Sarmiento; D Sakata; T Sasaki; I Sechopoulos; E C Simpson; T Toshito; D H Wright Journal: Med Phys Date: 2020-12-12 Impact factor: 4.071
Authors: Valentina Bravatà; Walter Tinganelli; Francesco P Cammarata; Luigi Minafra; Marco Calvaruso; Olga Sokol; Giada Petringa; Giuseppe A P Cirrone; Emanuele Scifoni; Giusi I Forte; Giorgio Russo Journal: J Pers Med Date: 2021-04-16