M Zamiri1, N J Wilson2, E A O'Toole3, F J D Smith2,4. 1. Alan Lyell Centre for Dermatology, Queen Elizabeth University Hospital, Glasgow, U.K. 2. Dermatology and Genetic Medicine, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, U.K. 3. Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, U.K. 4. Pachyonychia Congenita Project, Holladay, Utah, U.S.A.