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Literature DB >> 30820812

Transplantation of umbilical cord-derived mesenchymal stem cells on a collagen scaffold improves ovarian function in a premature ovarian failure model of mice.

Yanjun Yang^1,2, Lei Lei^2,3, Shanshan Wang², Xiaoqiang Sheng², Guijun Yan², Lu Xu², Jingyu Liu², Mengyuan Liu², Xin Zhen², Lijun Ding^4,5, Haixiang Sun^6,7.

Abstract

Premature ovarian failure (POF) is a refractory disease; one of the most important goals of treatment is to improve fertility. In the study, collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells (collagen/UC-MSCs) transplantation in POF mice preserved ovarian function, as supported by increased estrogen (E2) and anti-Mullerian hormone (AMH) levels, increased ovarian volume, and an increased number of antral follicles. Immunohistochemistry results of Ki67 indicated transplantation of collagen/UC-MSCs promoted granulosa cell proliferation, which is crucial to oocyte maturation and follicular development. Additionally, transplantation of collagen/UC-MSCs significantly promoted ovarian angiogenesis with the increased expression of CD31. In general, collagen/UC-MSCs transplantation probably is an effective therapeutic strategy of POF.

Entities: Disease Gene Species

Keywords: Collagen scaffold; Ovarian function; POF; UC-MSCs

Mesh：

Substances：
Hormones
Collagen

Year: 2019 PMID： 30820812 DOI： 10.1007/s11626-019-00337-4

Source DB: PubMed Journal: In Vitro Cell Dev Biol Anim ISSN： 1071-2690 Impact factor: 2.416

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Cited

23 in total

Review 1. Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure.

Authors: Oldouz Shareghi-Oskoue; Leili Aghebati-Maleki; Mehdi Yousefi
Journal: Stem Cell Res Ther Date: 2021-08-11 Impact factor: 8.079

2. UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system.

Authors: Wenjuan Xu; Caiyun Wu; Xiaoqian Zhu; Jingjing Wu; Zhiguo Zhang; Zhaolian Wei; Yunxia Cao; Ping Zhou; Jianye Wang
Journal: Stem Cell Res Ther Date: 2022-07-15 Impact factor: 8.079

Review 3. Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies.

Authors: In-Sun Hong
Journal: Front Cell Dev Biol Date: 2022-07-05

4. Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism.

Authors: Taoran Deng; Jing He; Qingyun Yao; Linjing Wu; Liru Xue; Mingfu Wu; Dongcheng Wu; Changyong Li; Yufeng Li
Journal: Reprod Sci Date: 2021-03-09 Impact factor: 3.060

Review 5. Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency.

Authors: Mara Ulin; Esra Cetin; Elie Hobeika; Rishi Man Chugh; Hang-Soo Park; Sahar Esfandyari; Ayman Al-Hendy
Journal: Reprod Sci Date: 2021-05-06 Impact factor: 3.060

6. Vitamin C improves the therapeutic potential of human amniotic epithelial cells in premature ovarian insufficiency disease.

Authors: Shunyu Hou; Chenyue Ding; Han Shen; Chunfeng Qian; Qinyan Zou; Jiafeng Lu; Boxian Huang; Jichun Tan; Hong Li
Journal: Stem Cell Res Ther Date: 2020-04-22 Impact factor: 6.832

Transplantation of umbilical cord-derived mesenchymal stem cells on a collagen scaffold improves ovarian function in a premature ovarian failure model of mice.

Review 1. Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure.

2. UC-MSCs promote frozen-thawed ovaries angiogenesis via activation of the Wnt/β-catenin pathway in vitro ovarian culture system.

Review 3. Enhancing Stem Cell-Based Therapeutic Potential by Combining Various Bioengineering Technologies.

4. Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism.

Review 5. Human Mesenchymal Stem Cell Therapy and Other Novel Treatment Approaches for Premature Ovarian Insufficiency.

6. Vitamin C improves the therapeutic potential of human amniotic epithelial cells in premature ovarian insufficiency disease.

Review 7. Therapeutic Potential of HUMSCs in Female Reproductive Aging.

Review 8. Using Mesenchymal Stem Cells to Treat Female Infertility: An Update on Female Reproductive Diseases.

Review 9. Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility.

Review 10. Therapeutic Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Female Reproductive Diseases.