Literature DB >> 3082066

Pancreatic endocrine carcinoma with ectopic PTH-production and paraneoplastic hypercalcaemia.

H Arps, M Dietel, A Schulz, H Janzarik, G Klöppel.   

Abstract

In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.

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Year:  1986        PMID： 3082066     DOI： 10.1007/bf00705303

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  14 in total

Review 1.  The biosynthesis of hormones by non-endocrine tumours--a review.

Authors:  L H Rees
Journal:  J Endocrinol       Date:  1975-10       Impact factor: 4.286

2.  Synthesis and release of parathyroid hormone by a renal carcinoma in cell culture.

Authors:  P B Greenberg; T J Martin; H S Sutcliffe
Journal:  Clin Sci Mol Med       Date:  1973-08

3.  Ectopic secretion of parathyroid hormone by a renal adenocarcinoma in a patient with hypercalcaemia.

Authors:  R M Buckle; M McMillan; C Mallinson
Journal:  Br Med J       Date:  1970-12-19

4.  Influence on parathyroid hormone storage in normal and adenomatous parathyroid tissue by stimulation and inhibition in vitro.

Authors:  M Dietel; F Hölzel
Journal:  J Histochem Cytochem       Date:  1983-02       Impact factor: 2.479

5.  Immunohistochemistry in detection of paraneoplastic secretion of calcium regulating hormones.

Authors:  H Arps; M Dietel; U Otto
Journal:  Folia Histochem Cytobiol       Date:  1984       Impact factor: 1.698

6.  Exocrine pancreatic cancer with humoral hypercalcemia.

Authors:  S Monno; A Nagata; T Homma; H Oguchi; S Kawa; R Kaji; S Furuta
Journal:  Am J Gastroenterol       Date:  1984-02       Impact factor: 10.864

7.  Immunochemical localization of parathyroid hormone in cancer tissue from patients with ectopic hyperparathyroidism.

Authors:  G M Palmieri; R E Nordquist; G S Omenn
Journal:  J Clin Invest       Date:  1974-06       Impact factor: 14.808

8.  Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer.

Authors:  B L Riggs; C D Arnaud; J C Reynolds; L H Smith
Journal:  J Clin Invest       Date:  1971-10       Impact factor: 14.808

9.  Alpha-human chorionic gonadotropin and neuron-specific enolase as markers for malignancy and neuroendocrine nature of pancreatic endocrine tumors.

Authors:  G Klöppel; J Girard; J M Polak; J L Vaitukaitis; M Kasper; P U Heitz
Journal:  Cancer Detect Prev       Date:  1983

10.  IMMUNOCHEMICAL IDENTIFICATION OF PARATHYROID HORMONE IN NON-PARATHYROID NEOPLASMS ASSOCIATED WITH HYPERCALCEMIA.

Authors:  A H TASHJIAN; L LEVINE; P L MUNSON
Journal:  J Exp Med       Date:  1964-03-01       Impact factor: 14.307
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  2 in total

1.  Ectopic secretion of parathyroid hormone in a neuroendocrine tumor: a case report and review of the literature.

Authors:  Emad Kandil; Salem Noureldine; Mohamed Abdel Khalek; Philip Daroca; Paul Friedlander
Journal:  Int J Clin Exp Med       Date:  2011-09-15

2.  Parathyroid hormone-related peptide in pancreatic neuroendocrine tumours associated with hypercalcaemia.

Authors:  I M Papazachariou; I T Virlos; R C Williamson
Journal:  HPB (Oxford)       Date:  2001       Impact factor: 3.647
  2 in total

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