| Literature DB >> 30820644 |
Muhammad Shahzad1, Manzoor Hussain2, Muhammad Shafique3, Rukhsana Perveen2, Nadeem Sheikh2.
Abstract
Insertion-deletion polymorphism (Indels) is valuable diallelic markers for forensic as well as parentage analysis. The Investigator DIPplex Kit (Qiagen) contains thirty autosomal Indels markers along with amelogenin. These thirty markers were tested in the Pakistani Punjabi Population but no significant deviations were observed from Hardy-Weinberg equilibrium rule expectations (Bonferroni corrected) except HLD58, HLD56, HLD99, and HLD40. The mean expected and observed heterozygosity was found 0.4701 and 0.4667 respectively; combined matching probability was computed as 7.31867 × 10-13. However, the use of the 30 Indels markers proved to be a good supplementary tool in forensic casework, particularly when evidence sample is highly degraded. The significant genetic differences were also observed between the Punjabi and other populations of the world.Entities:
Keywords: Forensic parameters; Indels; Pakistan; Punjabi population
Year: 2019 PMID: 30820644 DOI: 10.1007/s00414-019-02029-w
Source DB: PubMed Journal: Int J Legal Med ISSN: 0937-9827 Impact factor: 2.686