Cláudia Virgínia Louro Farinha1,2,3, Maria Luz Cachulo4,5,6, Dalila Alves4, Isabel Pires4,5,6, João Pedro Marques4,5,6, Patrícia Barreto4, Sandrina Nunes4, José Costa4,5,6, Amélia Martins4,5, Isa Sobral4,5,6, Inês Laíns5,6,7, João Figueira4,5,6, Luísa Ribeiro4,6, José Cunha-Vaz4,6, Rufino Silva4,5,6,8. 1. AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal, cvfarinha@aibili.pt. 2. Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal, cvfarinha@aibili.pt. 3. Faculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal, cvfarinha@aibili.pt. 4. AIBILI - Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal. 5. Ophthalmology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal. 6. Faculty of Medicine, University of Coimbra (FMUC), Coimbra, Portugal. 7. Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. 8. Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra (iCBR-FMUC), Coimbra, Portugal.
Abstract
PURPOSE: To describe the 6.5-year incidence and progression of age-related macular degeneration (AMD) in a coastal town of central Portugal. METHODS: Population-based cohort study. Participants underwent standardized interviews and ophthalmological examination. Color fundus photographs were graded according to the International Classification and Grading System for AMD and ARM. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analyzed. RESULTS: The 6.5-year cumulative incidence of early AMD was 10.7%, and of late AMD it was 0.8%. The incidence of early AMD was 7.2, 13.1 and 17.7% for participants aged 55-64, 65-74 and 75-84 years (p < 0.001). The late AMD incidence was 0.3, 0.9 and 2.8% for the corresponding age groups (p = 0.003). The age-standardized incidence was 10.8% (95% CI, 10.74-10.80%) for early and 1.0% (95% CI, 1.00-1.02%) for late AMD. The incidence of both neovascular AMD and geographic atrophy was 0.4%. Progression occurred in 17.2% of patients. CONCLUSION: The early AMD incidence in a coastal town of central Portugal was found to be similar to that of major epidemiological studies of European-descent populations; however, the incidence of late AMD was lower, and further analysis on risk factors will be conducted.
PURPOSE: To describe the 6.5-year incidence and progression of age-related macular degeneration (AMD) in a coastal town of central Portugal. METHODS: Population-based cohort study. Participants underwent standardized interviews and ophthalmological examination. Color fundus photographs were graded according to the International Classification and Grading System for AMD and ARM. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analyzed. RESULTS: The 6.5-year cumulative incidence of early AMD was 10.7%, and of late AMD it was 0.8%. The incidence of early AMD was 7.2, 13.1 and 17.7% for participants aged 55-64, 65-74 and 75-84 years (p < 0.001). The late AMD incidence was 0.3, 0.9 and 2.8% for the corresponding age groups (p = 0.003). The age-standardized incidence was 10.8% (95% CI, 10.74-10.80%) for early and 1.0% (95% CI, 1.00-1.02%) for late AMD. The incidence of both neovascular AMD and geographic atrophy was 0.4%. Progression occurred in 17.2% of patients. CONCLUSION: The early AMD incidence in a coastal town of central Portugal was found to be similar to that of major epidemiological studies of European-descent populations; however, the incidence of late AMD was lower, and further analysis on risk factors will be conducted.
Authors: Thomas J Heesterbeek; Laura Lorés-Motta; Carel B Hoyng; Yara T E Lechanteur; Anneke I den Hollander Journal: Ophthalmic Physiol Opt Date: 2020-02-25 Impact factor: 3.117
Authors: Peter M J Quinn; Paula I Moreira; António Francisco Ambrósio; C Henrique Alves Journal: Acta Neuropathol Commun Date: 2020-11-09 Impact factor: 7.801
Authors: Christina A Korb; Hisham Elbaz; Alexander K Schuster; Stefan Nickels; Katharina A Ponto; Andreas Schulz; Philipp S Wild; Thomas Münzel; Manfred E Beutel; Irene Schmidtmann; Karl J Lackner; Tunde Peto; Norbert Pfeiffer Journal: Graefes Arch Clin Exp Ophthalmol Date: 2021-08-23 Impact factor: 3.117