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Literature DB >> 30819909

Genetic loss of Tmprss6 alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia.

David B Stagg¹, Rebecca L Whittlesey², Xiuqi Li³, Larisa Lozovatsky³, Sara Gardenghi^4,5, Stefano Rivella^4,5,6, Karin E Finberg^7,3.

Abstract

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2019 PMID： 30819909 PMCID： PMC6886429 DOI： 10.3324/haematol.2018.213371

Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941

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15 in total

Review 1. Protein quality control during erythropoiesis and hemoglobin synthesis.

Authors: Eugene Khandros; Mitchell J Weiss
Journal: Hematol Oncol Clin North Am Date: 2010-12 Impact factor: 3.722

2. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

Authors: Sara Gardenghi; Pedro Ramos; Maria Franca Marongiu; Luca Melchiori; Laura Breda; Ella Guy; Kristen Muirhead; Niva Rao; Cindy N Roy; Nancy C Andrews; Elizabeta Nemeth; Antonia Follenzi; Xiuli An; Narla Mohandas; Yelena Ginzburg; Eliezer A Rachmilewitz; Patricia J Giardina; Robert W Grady; Stefano Rivella
Journal: J Clin Invest Date: 2010-11-22 Impact factor: 14.808

3. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis.

Authors: Ke Chen; Jing Liu; Susanne Heck; Joel A Chasis; Xiuli An; Narla Mohandas
Journal: Proc Natl Acad Sci U S A Date: 2009-09-28 Impact factor: 11.205

4. Erythroferrone and matriptase-2 independently regulate hepcidin expression.

Authors: Sharraya Aschemeyer; Victoria Gabayan; Tomas Ganz; Elizabeta Nemeth; Léon Kautz
Journal: Am J Hematol Date: 2017-02-24 Impact factor: 10.047

5. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.

Authors: Stela McLachlan; Kathryn E Page; Seung-Min Lee; Alex Loguinov; Erika Valore; Simon T Hui; Grace Jung; Jie Zhou; Aldons J Lusis; Brie Fuqua; Tomas Ganz; Elizabeta Nemeth; Chris D Vulpe
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2017-08-10 Impact factor: 4.052

6. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.

Authors: Sara Gardenghi; Maria F Marongiu; Pedro Ramos; Ella Guy; Laura Breda; Amy Chadburn; YiFang Liu; Ninette Amariglio; Gideon Rechavi; Eliezer A Rachmilewitz; William Breuer; Z Ioav Cabantchik; Diedra M Wrighting; Nancy C Andrews; Maria de Sousa; Patricia J Giardina; Robert W Grady; Stefano Rivella
Journal: Blood Date: 2007-02-13 Impact factor: 22.113

Genetic loss of Tmprss6 alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia.

Review 1. Protein quality control during erythropoiesis and hemoglobin synthesis.

2. Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.

3. Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis.

4. Erythroferrone and matriptase-2 independently regulate hepcidin expression.

5. Hamp1 mRNA and plasma hepcidin levels are influenced by sex and strain but do not predict tissue iron levels in inbred mice.

6. Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.

7. An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.

8. Transferrin therapy ameliorates disease in beta-thalassemic mice.

Review 9. Ineffective erythropoiesis and regulation of iron status in iron loading anaemias.

10. Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.

Review 1. Ineffective Erythropoiesis in β-Thalassaemia: Key Steps and Therapeutic Options by Drugs.

Review 2. The Role of Iron in Benign and Malignant Hematopoiesis.