Emergence of "Big Data" and Its Potential and Current Limitations in Medical Imaging.

Although electronic imaging was performed in the early 1950s in nuclear medicine, it was the introduction of computed tomography in 1972 that caused a revolution in medical imaging in that it marked the beginning of the inevitable transformation to digital imaging. This transformation is now more or less complete. While initially these CT images were relatively small, comprised of only about 6400 pixels per slice, the steady move toward higher spatial resolution, multislice imaging, digital radiography, and fluoroscopy rapidly increased the size of images and the amount of data required to be stored, processed, displayed, and moved about in a medical imaging department. The more recent introduction of digital pathology with submicron-sized pixels and the need for color further increases these demands. Rising work volumes in hospital, a push for cost containment, and a move toward greater precision in diagnosis and treatment of disease all work together to motivate the development of automated image analysis algorithms and techniques to improve efficiencies in in vivo imaging and pathology. This may require bringing together information from different imaging and nonimaging sources within the institution. While technological development has provided practical means for storage of the burgeoning data load and the use of multiple processors and high-speed networks has enabled more sophisticated analysis locally or in the cloud, challenges remain in terms of the ability to integrate data from different systems, the development of appropriately annotated image bases for training and testing of algorithms, and issues around privacy and ownership in obtaining access to patient-related data.