Literature DB >> 3081925

Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.

N R Swerdlow, M A Geyer, W W Vale, G F Koob.   

Abstract

A series of experiments was performed to investigate the effects of corticotropin-releasing factor (CRF) on the amplitude of the acoustic startle response (ASR) in rats. Intracerebroventricular (ICV) administration of 1 microgram rat CRF significantly potentiated acoustic startle amplitude; these effects were reversed in a dose-dependent manner by pretreatment with the benzodiazepine chlordiazepoxide (CDP). Doses of CDP that antagonized CRF-potentiated ASR did not lower startle baseline or antagonize amphetamine- or strychnine-potentiated ASR. These results suggest that CRF has "anxiogenic" properties and may serve as a neuroendocrine modulator of stress-enhanced behaviors.

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Year:  1986        PMID： 3081925     DOI： 10.1007/bf00652231

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  27 in total

1.  Motivational effects of drugs: Methods which ilustrate some general problems in psychopharmacology.

Authors:  N E MILLER; H BARRY
Journal:  Psychopharmacologia       Date:  1960-02-12

2.  The effects of pimozide and phenoxybenzamine pretreatments on amphetamine and apomorphine potentiation of the acoustic startle response in rats.

Authors:  J H Kehne; C A Sorenson
Journal:  Psychopharmacology (Berl)       Date:  1978-07-06       Impact factor: 4.530

3.  Behavioral factors in habituation of acoustic startle reactions.

Authors:  H S Hoffman; C Stitt
Journal:  J Comp Physiol Psychol       Date:  1969-06

4.  Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus.

Authors:  R J Valentino; S L Foote; G Aston-Jones
Journal:  Brain Res       Date:  1983-07-04       Impact factor: 3.252

5.  Corticotropin releasing factor produces behavioural activation in rats.

Authors:  R E Sutton; G F Koob; M Le Moal; J Rivier; W Vale
Journal:  Nature       Date:  1982-05-27       Impact factor: 49.962

6.  Conditioned fear and startle magnitude: effects of different footshock or backshock intensities used in training.

Authors:  M Davis; D I Astrachan
Journal:  J Exp Psychol Anim Behav Process       Date:  1978-04

7.  Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty.

Authors:  D R Britton; G F Koob; J Rivier; W Vale
Journal:  Life Sci       Date:  1982-07-26       Impact factor: 5.037

8.  Strychnine: brainstem and spinal mediation of excitatory effects on acoustic startle.

Authors:  J H Kehne; D W Gallager; M Davis
Journal:  Eur J Pharmacol       Date:  1981-12-03       Impact factor: 4.432

9.  Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats.

Authors:  C L Ehlers; S J Henriksen; M Wang; J Rivier; W Vale; F E Bloom
Journal:  Brain Res       Date:  1983-11-14       Impact factor: 3.252

10.  Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study.

Authors:  L W Swanson; P E Sawchenko; J Rivier; W W Vale
Journal:  Neuroendocrinology       Date:  1983       Impact factor: 4.914
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  72 in total

1.  Chronic anabolic androgenic steroid exposure alters corticotropin releasing factor expression and anxiety-like behaviors in the female mouse.

Authors:  Beth A Costine; Joseph G Oberlander; Matthew C Davis; Carlos A A Penatti; Donna M Porter; Robert N Leaton; Leslie P Henderson
Journal:  Psychoneuroendocrinology       Date:  2010-05-26       Impact factor: 4.905

2.  Alcohol stress response dampening: selective reduction of anxiety in the face of uncertain threat.

Authors:  Kathryn R Hefner; John J Curtin
Journal:  J Psychopharmacol       Date:  2011-09-21       Impact factor: 4.153

Review 3.  Evidence for the role of corticotropin-releasing factor in major depressive disorder.

Authors:  R Parrish Waters; Marion Rivalan; D A Bangasser; J M Deussing; M Ising; S K Wood; F Holsboer; Cliff H Summers
Journal:  Neurosci Biobehav Rev       Date:  2015-08-10       Impact factor: 8.989

4.  Restraint stress-induced reduction in prepulse inhibition in Brown Norway rats: role of the CRF2 receptor.

Authors:  Jane E Sutherland; Lisa H Conti
Journal:  Neuropharmacology       Date:  2010-12-23       Impact factor: 5.250

5.  Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structures.

Authors:  Kelly S Sink; David L Walker; Yong Yang; Michael Davis
Journal:  J Neurosci       Date:  2011-02-02       Impact factor: 6.167

6.  Differences in fear motivated behaviors among inbred mouse strains.

Authors:  R Trullas; P Skolnick
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 7.  The predator odor avoidance model of post-traumatic stress disorder in rats.

Authors:  Lucas Albrechet-Souza; Nicholas W Gilpin
Journal:  Behav Pharmacol       Date:  2019-04       Impact factor: 2.293

Review 8.  Molecular and genetic substrates linking stress and addiction.

Authors:  Lisa A Briand; Julie A Blendy
Journal:  Brain Res       Date:  2009-11-10       Impact factor: 3.252

9.  Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice.

Authors:  Victoria B Risbrough; Richard L Hauger; Mary Ann Pelleymounter; Mark A Geyer
Journal:  Psychopharmacology (Berl)       Date:  2003-07-04       Impact factor: 4.530

Review 10.  Physiological and neurochemical aspects of corticotropin-releasing factor actions in the brain: the role of the locus coeruleus.

Authors:  H Lehnert; C Schulz; K Dieterich
Journal:  Neurochem Res       Date:  1998-08       Impact factor: 3.996
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