Ann M Vuong1, Kimberly Yolton2, Changchun Xie3, Kim N Dietrich4, Joseph M Braun5, Glenys M Webster6, Antonia M Calafat7, Bruce P Lanphear6, Aimin Chen4. 1. Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267, USA. Electronic address: ann.vuong@uc.edu. 2. Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7035, Cincinnati, OH 45229, USA. 3. Division of Biostatistics and Bioinformatics, Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267, USA. 4. Division of Epidemiology, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267, USA. 5. Department of Epidemiology, Brown University School of Public Health, 121 South Main St, Box G-S121-2, Providence, RI 02912, USA. 6. BC Children's Hospital Research Institute and Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6. 7. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Abstract
BACKGROUND: Toxicological studies indicate that poly- and perfluoroalkyl substances (PFAS) may be neurotoxic, but human studies have yet to provide compelling evidence for PFAS' impact on cognitive abilities. OBJECTIVE: To test whether prenatal and childhood PFAS are associated with cognitive abilities at 8 years and whether sex modifies these associations. METHODS: We included 221 mother-child pairs from the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort in Cincinnati, OH (USA). We quantified PFAS in maternal serum at 16 ± 3 weeks gestation and in child serum at 3 and 8 years. We used the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) at age 8 years, assessing Full Scale IQ (FSIQ), verbal comprehension, perceptual reasoning, working memory, and processing speed. We used multiple informant models to estimate covariate-adjusted differences in WISC-IV scores by repeated ln-transformed PFAS. RESULTS: Prenatal and childhood perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were not associated with WISC-IV measures. We observed an increase of 4.1-points (95% CI 0.3, 8.0) and 5.7-points (95% CI 1.2, 10.2) in working memory with 1-ln unit increase in prenatal perfluorooctanoate (PFOA) and perfluorononanoate (PFNA), respectively. In addition, PFNA at 3 years was associated with better FSIQ and perceptual reasoning. Child sex modified the relationship between prenatal PFOA and FSIQ; the association was positive in females only. Sex also modified the association between concurrent PFOS and FSIQ, with males having higher scores. CONCLUSION: We did not observe adverse associations between prenatal and childhood PFAS and cognitive function at age 8 years.
BACKGROUND: Toxicological studies indicate that poly- and perfluoroalkyl substances (PFAS) may be neurotoxic, but human studies have yet to provide compelling evidence for PFAS' impact on cognitive abilities. OBJECTIVE: To test whether prenatal and childhood PFAS are associated with cognitive abilities at 8 years and whether sex modifies these associations. METHODS: We included 221 mother-child pairs from the Health Outcomes and Measures of the Environment (HOME) Study, a birth cohort in Cincinnati, OH (USA). We quantified PFAS in maternal serum at 16 ± 3 weeks gestation and in child serum at 3 and 8 years. We used the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) at age 8 years, assessing Full Scale IQ (FSIQ), verbal comprehension, perceptual reasoning, working memory, and processing speed. We used multiple informant models to estimate covariate-adjusted differences in WISC-IV scores by repeated ln-transformed PFAS. RESULTS: Prenatal and childhood perfluorooctane sulfonate (PFOS) and perfluorohexane sulfonate (PFHxS) were not associated with WISC-IV measures. We observed an increase of 4.1-points (95% CI 0.3, 8.0) and 5.7-points (95% CI 1.2, 10.2) in working memory with 1-ln unit increase in prenatal perfluorooctanoate (PFOA) and perfluorononanoate (PFNA), respectively. In addition, PFNA at 3 years was associated with better FSIQ and perceptual reasoning. Child sex modified the relationship between prenatal PFOA and FSIQ; the association was positive in females only. Sex also modified the association between concurrent PFOS and FSIQ, with males having higher scores. CONCLUSION: We did not observe adverse associations between prenatal and childhood PFAS and cognitive function at age 8 years.
Authors: Joseph M Braun; Geetika Kalloo; Aimin Chen; Kim N Dietrich; Stacey Liddy-Hicks; Samantha Morgan; Yingying Xu; Kimberly Yolton; Bruce P Lanphear Journal: Int J Epidemiol Date: 2017-02-01 Impact factor: 7.196
Authors: Kathrine Eggers Pedersen; Niladri Basu; Robert Letcher; Alana K Greaves; Christian Sonne; Rune Dietz; Bjarne Styrishave Journal: Environ Res Date: 2015-02-14 Impact factor: 6.498
Authors: Hongmei Zhang; Kimberly Yolton; Glenys M Webster; Xiaoyun Ye; Antonia M Calafat; Kim N Dietrich; Yingying Xu; Changchun Xie; Joseph M Braun; Bruce P Lanphear; Aimin Chen Journal: Environ Int Date: 2017-12-20 Impact factor: 9.621
Authors: Miranda J Spratlen; Frederica P Perera; Sally Ann Lederman; Virginia A Rauh; Morgan Robinson; Kurunthachalam Kannan; Leonardo Trasande; Julie Herbstman Journal: Environ Pollut Date: 2020-03-26 Impact factor: 8.071
Authors: Thea S Skogheim; Gro D Villanger; Kjell Vegard F Weyde; Stephanie M Engel; Pål Surén; Merete G Øie; Annette H Skogan; Guido Biele; Pål Zeiner; Kristin R Øvergaard; Line S Haug; Azemira Sabaredzovic; Heidi Aase Journal: Int J Hyg Environ Health Date: 2019-10-22 Impact factor: 5.840
Authors: Geetika Kalloo; Gregory A Wellenius; Lawrence McCandless; Antonia M Calafat; Andreas Sjodin; Adam J Sullivan; Megan E Romano; Margaret R Karagas; Aimin Chen; Kimberly Yolton; Bruce P Lanphear; Joseph M Braun Journal: Environ Res Date: 2021-03-18 Impact factor: 8.431
Authors: Albeliz Santiago-Colón; Robert Daniels; Dori Reissman; Kristi Anderson; Geoffrey Calvert; Alexis Caplan; Tania Carreón; Alan Katruska; Travis Kubale; Ruiling Liu; Rhonda Nembhard; W Allen Robison; James Yiin; John Howard Journal: Int J Environ Res Public Health Date: 2020-10-06 Impact factor: 3.390