| Literature DB >> 30818083 |
Seyed Mostafa Parizadeh1, Reza Jafarzadeh-Esfehani2, Seyed Mahdi Hassanian1, Seyed Mohammad Reza Parizadeh1, Samaneh Vojdani3, Maryam Ghandehari4, Anahita Ghazaghi5, Majid Khazaei1, Soodabeh Shahidsales6, Majid Rezayi1, Fereshteh Asgharzadeh1, Majid Ghayour-Mobarhan1, Gordon A Ferns7, Amir Avan8.
Abstract
Colorectal cancer is one of the most common cancers globally. A large portion of colorectal cancer patients who are treated with conventional chemotherapy eventually develop local recurrence or metastases. The failure of a complete cure in colorectal cancer patients may be related to the lack of complete eradication of cancer stem cells when using conventional therapy. Colorectal cancer stem cells comprise a small population of tumor cells that possess the properties of rapid proliferation and differentiation. The colorectal cancer stem cells are also phenotypically and molecularly distinct, and resistant to conventional chemo-radiotherapy. Therefore, it is important to identify approaches in combination with conventional therapy for targeting and eradicating cancer cells. The aim of this review was to summarize the main findings of recent studies on targeting colorectal cancer stem cells as a novel therapeutic approach in colorectal cancer treatment.Entities:
Keywords: Cancer stem cells; Colorectal cancer; Conventional; Target; Therapy
Year: 2019 PMID： 30818083 DOI： 10.1016/j.biocel.2019.02.010
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085