INTRODUCTION AND AIM: Multifocal motor neuropathy (MMN) is a rare, chronic disorder with potentially severe and progressive disability, which may affect patients' quality of life (QoL). Since there is still small number of studies that predominantly investigated QoL in patients with MMN, we sought to analyze QoL in these patients. MATERIALS AND METHODS: Our study comprised 17 patients diagnosed with MMN at the same clinic. Following scales were used: SF-36 questionnaire, INCAT disability scale, Krupp's Fatigue Severity scale, and Beck Depression Inventory. RESULTS: Physical domains of QoL were slightly more affected than mental ones, but with no statistical significance (64.8 ± 22.3 vs. 70.0 ± 19.5, p > 0.05). Total SF-36 score was 69.2 ± 19.9. INCAT arm disability score at testing was found to correlate with the total SF-36 score (rho = -0.603, p < 0.05). INCAT arm disability score at diagnosis (rho = -0.57, p < 0.05) and at testing (rho = -0.48, p = 0.05) correlated with physical composite score (PCS). Disease duration (rho = -0.51, p < 0.05) and INCAT arm disability score at testing (rho = -0.60, p = 0.01) were associated with mental composite score (MCS). CONCLUSION: QoL in patients with MMN was reduced, especially in physical domains. Although arm disability was the most significant parameter which affected QoL of MMN patients in both physical and mental aspects, longer disease duration should not be underestimated as a psychological burden for these patients.
INTRODUCTION AND AIM: Multifocal motor neuropathy (MMN) is a rare, chronic disorder with potentially severe and progressive disability, which may affect patients' quality of life (QoL). Since there is still small number of studies that predominantly investigated QoL in patients with MMN, we sought to analyze QoL in these patients. MATERIALS AND METHODS: Our study comprised 17 patients diagnosed with MMN at the same clinic. Following scales were used: SF-36 questionnaire, INCAT disability scale, Krupp's Fatigue Severity scale, and Beck Depression Inventory. RESULTS: Physical domains of QoL were slightly more affected than mental ones, but with no statistical significance (64.8 ± 22.3 vs. 70.0 ± 19.5, p > 0.05). Total SF-36 score was 69.2 ± 19.9. INCAT arm disability score at testing was found to correlate with the total SF-36 score (rho = -0.603, p < 0.05). INCAT arm disability score at diagnosis (rho = -0.57, p < 0.05) and at testing (rho = -0.48, p = 0.05) correlated with physical composite score (PCS). Disease duration (rho = -0.51, p < 0.05) and INCAT arm disability score at testing (rho = -0.60, p = 0.01) were associated with mental composite score (MCS). CONCLUSION: QoL in patients with MMN was reduced, especially in physical domains. Although arm disability was the most significant parameter which affected QoL of MMNpatients in both physical and mental aspects, longer disease duration should not be underestimated as a psychological burden for these patients.
Authors: Eva-Maria Skoda; Mark Stettner; Venja Musche; Alexander Bäuerle; Lisa Jahre; Adam Schweda; Hannah Dinse; Sheila Moradian; Benjamin Weismüller; Madeleine Fink; Anna Wolters; Michael Fleischer; Christoph Kleinschnitz; Martin Teufel Journal: Neurol Ther Date: 2022-05-12