C Elizabeth Shaaban1,2, Howard Jay Aizenstein2,3, Dana R Jorgensen1,2, Rebecca L M Mahbubani3, Nicole A Meckes4, Kirk I Erickson2,5, Nancy W Glynn1, Joseph Mettenburg6, Jack Guralnik7, Anne B Newman1, Tamer S Ibrahim6,8, Paul J Laurienti9,10, Abbe N Vallejo11,12, Caterina Rosano1,2. 1. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA. 2. Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA. 3. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA. 4. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA. 5. Department of Psychology, University of Pittsburgh, Pittsburgh, PA. 6. Department of Radiology, University of Pittsburgh, Pittsburgh, PA. 7. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD. 8. Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA. 9. Laboratory for Complex Brain Networks, Wake Forest University School of Medicine, Winston-Salem, NC. 10. Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC. 11. Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA. 12. Department of Immunology, University of Pittsburgh, Pittsburgh, PA.
Abstract
Identifying promoters of cerebral small vein integrity is important to counter vascular contributions to cognitive impairment and dementia. PURPOSE: In this preliminary investigation, the effects of a randomized 24-month physical activity (PA) intervention on changes in cerebral small vein integrity were compared to those of a health education (HE) control. METHODS:Cerebral small vein integrity was measured in 24 older adults (n = 8, PA; n = 16, HE) using ultra-high field MRI before and at the end of the 24-month intervention. Deep medullary veins were defined as straight or tortuous; percent change in straight length, tortuous length, and tortuosity ratio were computed. Microbleed count and white matter hyperintensities were also rated. RESULTS:Accelerometry-based values of PA increased by 17.2% in the PA group but declined by 28.0% in the HE group. The PA group, but not the HE group, had a significant increase in straight vein length from baseline to 24-month follow-up (P = 0.02 and P = 0.21, respectively); the between-group difference in percent change in straight length was significant (increase: median, 93.6%; interquartile range, 112.9 for PA; median, 28.4%; interquartile range, 90.6 for HE; P = 0.07). Between group differences in other markers were nonsignificant. CONCLUSIONS: Increasing PA in late-life may promote cerebral small vein integrity. This should be confirmed in larger studies.
RCT Entities:
Identifying promoters of cerebral small vein integrity is important to counter vascular contributions to cognitive impairment and dementia. PURPOSE: In this preliminary investigation, the effects of a randomized 24-month physical activity (PA) intervention on changes in cerebral small vein integrity were compared to those of a health education (HE) control. METHODS: Cerebral small vein integrity was measured in 24 older adults (n = 8, PA; n = 16, HE) using ultra-high field MRI before and at the end of the 24-month intervention. Deep medullary veins were defined as straight or tortuous; percent change in straight length, tortuous length, and tortuosity ratio were computed. Microbleed count and white matter hyperintensities were also rated. RESULTS: Accelerometry-based values of PA increased by 17.2% in the PA group but declined by 28.0% in the HE group. The PA group, but not the HE group, had a significant increase in straight vein length from baseline to 24-month follow-up (P = 0.02 and P = 0.21, respectively); the between-group difference in percent change in straight length was significant (increase: median, 93.6%; interquartile range, 112.9 for PA; median, 28.4%; interquartile range, 90.6 for HE; P = 0.07). Between group differences in other markers were nonsignificant. CONCLUSIONS: Increasing PA in late-life may promote cerebral small vein integrity. This should be confirmed in larger studies.
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