Literature DB >> 3081630

Anti-Ly-1 antibody induces interleukin 2 release from T cells.

T Stanton, T L Stevens, J A Ledbetter, D Wofsy.   

Abstract

In this report we show that a signal provided by binding of anti-Ly-1 antibody to the Ly-1 cell surface protein, along with a second signal provided by mitogen, can trigger a T cell into activation and increase [Ca2+]i and the release of IL2. At optimal concentrations, the effects of anti-Ly-1 and IL 1 are additive, suggesting a different activation pathway for each.

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Year:  1986        PMID: 3081630

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  6 in total

1.  Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5.

Authors:  B E Bierer; Y Nishimura; S J Burakoff; B R Smith
Journal:  J Clin Invest       Date:  1988-05       Impact factor: 14.808

2.  B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes.

Authors:  J H Antin; K A Ault; J M Rappeport; B R Smith
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808

3.  Characterization of porcine CD5 and CD5+ B cells.

Authors:  G D Appleyard; B N Wilkie
Journal:  Clin Exp Immunol       Date:  1998-01       Impact factor: 4.330

4.  Potentiation of interleukin-2 production and its binding by monoclonal antibodies to the gangliosides GD3 and GD2.

Authors:  S Schibeci; P Hersey; D Cheresh
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

5.  Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes.

Authors:  L Biancone; M A Bowen; A Lim; A Aruffo; G Andres; I Stamenkovic
Journal:  J Exp Med       Date:  1996-09-01       Impact factor: 14.307

6.  CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.

Authors:  H S Azzam; A Grinberg; K Lui; H Shen; E W Shores; P E Love
Journal:  J Exp Med       Date:  1998-12-21       Impact factor: 14.307

  6 in total

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