BACKGROUND AND OBJECTIVES: There are limited data about the risk of asthma in people with diabetes. We examined the incidence of asthma in subjects with type 2 diabetes (T2DM) compared to controls, and the association with metformin, sulphonylureas and insulin therapy. MATERIALS AND METHODS: We conducted a retrospective cohort study using a representative UK primary care database (N = 894 646 adults). We used 1:1 propensity score matching (age, gender, socio-economic deprivation, body mass index and smoking status) to match 29 217 pairs of T2DM cases and controls. We used Cox proportional hazard regression to compare the incidence of asthma in both groups over 8 years of follow-up. In those with T2DM, we used Cox proportional hazard regression to assess for any impact of antidiabetic medications on asthma incidence. RESULTS: Individuals with T2DM were less likely to develop asthma than matched controls (hazard ratio [HR] 0.85, 95% CI 0.77-0.93). Insulin increased the risk of incident asthma (HR 1.25, 95% CI 1.01-1.56), whilst metformin and sulphonylureas were associated with reduced risk (HR 0.80, 95% CI 0.69-0.93 and HR 0.76, 95% CI 0.60-0.97, respectively). There was no association with diabetes duration, complications or glycaemic control. CONCLUSIONS: T2DM may have a protective effect against asthma development. Insulin use was associated with an increased risk of asthma, while metformin and sulphonylureas reduced the risk in those with T2DM.
BACKGROUND AND OBJECTIVES: There are limited data about the risk of asthma in people with diabetes. We examined the incidence of asthma in subjects with type 2 diabetes (T2DM) compared to controls, and the association with metformin, sulphonylureas and insulin therapy. MATERIALS AND METHODS: We conducted a retrospective cohort study using a representative UK primary care database (N = 894 646 adults). We used 1:1 propensity score matching (age, gender, socio-economic deprivation, body mass index and smoking status) to match 29 217 pairs of T2DM cases and controls. We used Cox proportional hazard regression to compare the incidence of asthma in both groups over 8 years of follow-up. In those with T2DM, we used Cox proportional hazard regression to assess for any impact of antidiabetic medications on asthma incidence. RESULTS: Individuals with T2DM were less likely to develop asthma than matched controls (hazard ratio [HR] 0.85, 95% CI 0.77-0.93). Insulin increased the risk of incident asthma (HR 1.25, 95% CI 1.01-1.56), whilst metformin and sulphonylureas were associated with reduced risk (HR 0.80, 95% CI 0.69-0.93 and HR 0.76, 95% CI 0.60-0.97, respectively). There was no association with diabetes duration, complications or glycaemic control. CONCLUSIONS: T2DM may have a protective effect against asthma development. Insulin use was associated with an increased risk of asthma, while metformin and sulphonylureas reduced the risk in those with T2DM.
Authors: Fu-Shun Yen; Chih-Cheng Hsu; Ying-Hsiu Shih; Wei-Lin Pan; James Cheng-Chung Wei; Chii-Min Hwu Journal: Int J Environ Res Public Health Date: 2022-07-05 Impact factor: 4.614
Authors: Fu-Shun Yen; Chih-Cheng Hsu; Kai-Chieh Hu; Yu-Tung Hung; Chung Y Hsu; James Cheng-Chung Wei; Chii-Min Hwu Journal: Int J Environ Res Public Health Date: 2022-09-03 Impact factor: 4.614
Authors: Dinah Foer; Patrick E Beeler; Jing Cui; Elizabeth W Karlson; David W Bates; Katherine N Cahill Journal: Am J Respir Crit Care Med Date: 2021-04-01 Impact factor: 21.405
Authors: Simon de Lusignan; Helen Alexander; Conor Broderick; John Dennis; Andrew McGovern; Claire Feeney; Carsten Flohr Journal: BMJ Open Date: 2020-09-16 Impact factor: 2.692
Authors: Simon de Lusignan; Helen Alexander; Conor Broderick; John Dennis; Andrew McGovern; Claire Feeney; Carsten Flohr Journal: Clin Exp Allergy Date: 2020-11-26 Impact factor: 5.018