Literature DB >> 3081044

Entry of acetyl-L-carnitine into biosynthetic pathways.

S Farrell, J Vogel, L L Bieber.   

Abstract

[1-14C]Acetyl-L-carnitine was injected into fed and fasted mice and the time-course of distribution of 14C in various tissues and tissue components was determined. The major product was 14CO2. However, considerable quantities of radioactivity were localized in liver with much smaller quantities in heart, brain, skeletal muscle and kidney. Most of the 14C in liver was located in the fatty acids of phospholipids and triacylglycerols within 10 min after injection. The data demonstrate that the acetyl moiety of acetylcarnitine rapidly enters lipid biosynthetic pools in liver.

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Year:  1986        PMID： 3081044     DOI： 10.1016/0005-2760(86)90332-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

1.  Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain.

Authors:  Susanna Scafidi; Gary Fiskum; Steven L Lindauer; Penelope Bamford; Da Shi; Irene Hopkins; Mary C McKenna
Journal:  J Neurochem       Date:  2010-05-13       Impact factor: 5.372

2.  Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery.

Authors:  S P Patel; P G Sullivan; T S Lyttle; D S K Magnuson; A G Rabchevsky
Journal:  Neuroscience       Date:  2012-03-15       Impact factor: 3.590

3.  Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats.

Authors:  Thangaraj Annadurai; Shankaravadivelu Vigneshwari; Rajendran Thirukumaran; Philip A Thomas; Pitchairaj Geraldine
Journal:  J Physiol Biochem       Date:  2011-05-27       Impact factor: 4.158

Review 4.  Acetyl-L-carnitine in neuropathic pain: experimental data.

Authors:  Santina Chiechio; Agata Copani; Robert W Gereau; Ferdinando Nicoletti
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

5.  Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

Authors:  Deborah M Muoio; Robert C Noland; Jean-Paul Kovalik; Sarah E Seiler; Michael N Davies; Karen L DeBalsi; Olga R Ilkayeva; Robert D Stevens; Indu Kheterpal; Jingying Zhang; Jeffrey D Covington; Sudip Bajpeyi; Eric Ravussin; William Kraus; Timothy R Koves; Randall L Mynatt
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

Review 6.  Mitochondria in the elderly: Is acetylcarnitine a rejuvenator?

Authors:  Mariana G Rosca; Hélène Lemieux; Charles L Hoppel
Journal:  Adv Drug Deliv Rev       Date:  2009-08-29       Impact factor: 15.470

7.  Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.

Authors:  Mariano Malaguarnera; Giovanni Pistone; Marinella Astuto; Ignazio Vecchio; Rocco Raffaele; Emilia Lo Giudice; Liborio Rampello
Journal:  Dig Dis Sci       Date:  2006-11-01       Impact factor: 3.487

8.  Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets.

Authors:  Yuan-Yuan Li; Christelle Douillet; Madelyn Huang; Rowan Beck; Susan Jenkins Sumner; Miroslav Styblo
Journal:  Arch Toxicol       Date:  2020-04-10       Impact factor: 6.168

9.  Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.

Authors:  Robert C Noland; Timothy R Koves; Sarah E Seiler; Helen Lum; Robert M Lust; Olga Ilkayeva; Robert D Stevens; Fausto G Hegardt; Deborah M Muoio
Journal:  J Biol Chem       Date:  2009-06-24       Impact factor: 5.157

Review 10.  l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug.

Authors:  Santina Chiechio; Pier Luigi Canonico; Mariagrazia Grilli
Journal:  Int J Mol Sci       Date:  2017-12-21       Impact factor: 5.923
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