AIM: To investigate the role of the transcription factor YY1 in Wilms tumor (WT). PATIENTS & METHODS: We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical and protein expression was determined by digital pathology. RESULTS & CONCLUSION: YY1 significantly increased in WT patients. In addition, an increase in YY1 expression had a greater risk of adverse outcomes in WT patients with favorable histology. YY1 expression was higher in the blastemal component of tumors, and high nuclear expression positively correlated with metastasis. YY1 may be considered as a metastasis risk factor in WT.
AIM: To investigate the role of the transcription factor YY1 in Wilms tumor (WT). PATIENTS & METHODS: We measured YY1 expression using tissue microarray from patients with pediatric renal tumors, mainly WT and evaluated correlations with the predicted clinical evolution. YY1 expression was measured using immunohistochemical and protein expression was determined by digital pathology. RESULTS & CONCLUSION:YY1 significantly increased in WT patients. In addition, an increase in YY1 expression had a greater risk of adverse outcomes in WT patients with favorable histology. YY1 expression was higher in the blastemal component of tumors, and high nuclear expression positively correlated with metastasis. YY1 may be considered as a metastasis risk factor in WT.
Authors: Héctor I Saldivar-Cerón; Olga Villamar-Cruz; Claire M Wells; Ibrahim Oguz; Federica Spaggiari; Jonathan Chernoff; Genaro Patiño-López; Sara Huerta-Yepez; Mayra Montecillo-Aguado; Clara M Rivera-Pazos; Marco A Loza-Mejía; Alonso Vivar-Sierra; Paola Briseño-Díaz; Alejandro Zentella-Dehesa; Alfonso Leon-Del-Rio; Alejandro López-Saavedra; Laura Padierna-Mota; María de Jesús Ibarra-Sánchez; José Esparza-López; Rosaura Hernández-Rivas; Luis E Arias-Romero Journal: Front Cell Dev Biol Date: 2022-01-17