Li-Ting Kao1,2,3, Shih-Han Hung4,5, Pai-Feng Kao6, Ju-Chi Liu6,7, Herng-Ching Lin2,8. 1. Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan. 2. Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan. 3. Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan. 4. Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan. 5. Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan. 6. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 7. Division of Cardiovascular Medicine, Department of Medicine, Medical University Hospital--Shuang Ho Hospital, Taipei, Taiwan. 8. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.
Abstract
BACKGROUND: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. METHODS: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. RESULTS: Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. CONCLUSION: This study found an inverse association between statin usage and head and neck cancer occurrence.
BACKGROUND: This case-control study aimed to find the relationship between prior statin use and head and neck cancer occurrence using a large population-based database. METHODS: This study used claims data from the Taiwan Longitudinal Health Insurance Database. We included 5515 patients with head and neck cancer as cases and 5515 propensity score-matched patients without head and neck cancer as controls. Conditional logistic regressions were performed to investigate the relationship between head and neck cancer and prior statin exposure. RESULTS: Of the 11 030 total sampled patients, 16.95% had previously received prescriptions for statins. In addition, statin exposure was found in 15.99% of cases and 17.91% of controls. The logistic regression also revealed that the adjusted odds ratio of prior statin exposure for cases was 0.86 (95% confidence interval: 0.77-0.95) compared to propensity score-matched controls. CONCLUSION: This study found an inverse association between statin usage and head and neck cancer occurrence.
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