Qi Zhang1,2, Kanhua Yin3, Mingli Zhu2, Xinghui Lin2, Yan Fang2, Jiayue Lu2, Zhenyuan Li2, Zhaohui Ni2. 1. Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200011, PR China. 2. Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, PR China. 3. Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Abstract
Aim: To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients. Methods: We enrolled 311 patients (median age: 61 years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of 29.78 ng/ml. Ninety-six (30.7%) had arterial stiffness diagnosed by the pulse-wave velocity over 10 m/s. Results: Galectin-3 was significantly associated with dialysis vintage, calcium, phosphorus and low-density lipoprotein. After adjustment for multiple cardiovascular risk factors, galectin-3 was independently associated with the pulse-wave velocity (partial r = 0.130; p = 0.035). This effect was still significant after additional adjustment for mean arterial pressure and single-pool Kt/V (partial r = 0.139; p = 0.014). Conclusion: Galectin-3 is independently associated with arterial stiffness among hemodialysis patients.
Aim: To evaluate the association between galectin-3 and arterial stiffness among hemodialysis patients. Methods: We enrolled 311 patients (median age: 61 years) with a median hemodialysis time of 90 months and a mean galectin-3 concentration of 29.78 ng/ml. Ninety-six (30.7%) had arterial stiffness diagnosed by the pulse-wave velocity over 10 m/s. Results:Galectin-3 was significantly associated with dialysis vintage, calcium, phosphorus and low-density lipoprotein. After adjustment for multiple cardiovascular risk factors, galectin-3 was independently associated with the pulse-wave velocity (partial r = 0.130; p = 0.035). This effect was still significant after additional adjustment for mean arterial pressure and single-pool Kt/V (partial r = 0.139; p = 0.014). Conclusion:Galectin-3 is independently associated with arterial stiffness among hemodialysis patients.
Authors: Emily S Lau; Elizabeth Liu; Samantha M Paniagua; Amy A Sarma; Giovanna Zampierollo; Begoña López; Javier Díez; Thomas J Wang; Jennifer E Ho Journal: JACC Basic Transl Sci Date: 2021-01-06